DUSP11 Antibody

Code CSB-PA007240GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DUSP11
Alternative Names
DUSP11 antibody; PIR1RNA/RNP complex-1-interacting phosphatase antibody; EC 3.1.3.- antibody; Dual specificity protein phosphatase 11 antibody; Phosphatase that interacts with RNA/RNP complex 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DUSP11
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Gene References into Functions
  1. Results implicate DUSP11 as an important component of XRN-mediated restriction of hepatitis C virus replication. PMID: 30038017
  2. DUSP11 regulates host and viral non-coding RNAs in mammalian cells. PMID: 28296624
  3. PIR gene expression is highly dependent on the expression of HR-HPV E6 and E7 oncoproteins HPV-positive cell lines. PMID: 29118270
  4. DUSP11 converts the 5' triphosphate of miRNA precursors to a 5' monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5' monophosphate-dependent strand selection mechanism. PMID: 27798849
  5. the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution. PMID: 24447265
  6. results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68 PMID: 19120688

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Subcellular Location
Nucleus. Nucleus speckle.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Database Links

HGNC: 3066

OMIM: 603092

KEGG: hsa:8446

STRING: 9606.ENSP00000272444

UniGene: Hs.14611

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