DUSP9 Antibody

Code CSB-PA859528LA01HU
Size US$166
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Image
  • IHC image of CSB-PA859528LA01HU diluted at 1:600 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA859528LA01HU diluted at 1:600 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA859528LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DUSP9 Polyclonal antibody
Uniprot No.
Target Names
DUSP9
Alternative Names
Dual specificity phosphatase 9 antibody; Dual specificity protein phosphatase 9 antibody; DUS9_HUMAN antibody; DUSP9 antibody; MAP kinase phosphatase 4 antibody; Mitogen activated protein kinase phosphatase 4 antibody; Mitogen-activated protein kinase phosphatase 4 antibody; MKP 4 antibody; MKP-4 antibody; MKP4 antibody; serine/threonine specific protein phosphatase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dual specificity protein phosphatase 9 protein (142-263AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DUSP9 Antibody (Product code: CSB-PA859528LA01HU) is Non-conjugated. For DUSP9 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA859528LB01HU DUSP9 Antibody, HRP conjugated ELISA
FITC CSB-PA859528LC01HU DUSP9 Antibody, FITC conjugated
Biotin CSB-PA859528LD01HU DUSP9 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
IF 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inactivates MAP kinases. Has a specificity for the ERK family.
Gene References into Functions
  1. The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells. PMID: 25998184
  2. A possible use for DUSP9 as CIMP marker. PMID: 24838152
  3. DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia. PMID: 23276385
  4. The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes. PMID: 23029454
  5. decreased expression of DUSP-9 is associated with poor prognosis in ccRCC. PMID: 21943117
  6. 2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented PMID: 21206059
  7. microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP PMID: 18006813

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Subcellular Location
Cytoplasm.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Database Links

HGNC: 3076

OMIM: 300134

KEGG: hsa:1852

STRING: 9606.ENSP00000345853

UniGene: Hs.144879

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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