DYNC1I1 Antibody

Datasheet

Code	CSB-PA007293ESR1HU
Size	US$166
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Image	Western blot All lanes: DYNC1I1 antibody at 2.52µg/ml Lane 1: Mouse brain tissue Lane 2: Mouse gonadal tissue Lane 3: K562 whole cell lysate Lane 4: HL60 whole cell lysate Lane 5: Mouse lung tissue Lane 6: Mouse skeletal muscle tissue Lane 7: Mouse stomach tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 73, 71, 69, 68 kDa Observed band size: 73 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007293ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA007293ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DYNC1I1 Polyclonal antibody

Uniprot No.

O14576

Target Names

DYNC1I1

Alternative Names

Cytoplasmic dynein 1 intermediate chain 1 antibody; Cytoplasmic dynein intermediate chain 1 antibody; cytosolic antibody; DC1I1_HUMAN antibody; DH IC 1 antibody; DH IC-1 antibody; DH IC1 antibody; DNCI1 antibody; DNCIC1 antibody; Dync1i1 antibody; Dynein cytoplasmic 1 intermediate chain 1 antibody; Dynein intermediate chain 1 antibody; Dynein intermediate chain 1; cytosolic antibody; Dynein; cytoplasmic; intermediate polypeptide 1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 protein (1-220AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Gene References into Functions

SQSTM1 is required for proper dynein motility and trafficking along microtubules. PMID: 25015291
Deletions of the exons with regulatory potential of DYNC1I1 are an example of the emerging role of exonic enhancer elements and their implications in congenital malformation syndromes PMID: 25231166
NCAM and dynein have roles in tethering dynamic microtubules and maintaining synaptic density in cortical neurons PMID: 23960070
Both P-TEFb recruitment to the HIV long terminal repeat and enhanced HIV processivity were blocked by ERK inhibitor, but not by AKT and PI3K inhibitors. PMID: 21763495
the mRNA expression level of DYNC1I1 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts. PMID: 21767414
NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane. PMID: 20048338
identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24] PMID: 12006665

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Subcellular Location

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.

Protein Families

Dynein intermediate chain family

Database Links

HGNC: 2963

OMIM: 603772

KEGG: hsa:1780

STRING: 9606.ENSP00000320130

UniGene: Hs.440364

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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