EMCN Antibody

Code CSB-PA007632ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA007632ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007632ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EMCN Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
EMCN antibody; EMCN2 antibody; Endomucin 2 antibody; Endomucin antibody; Endomucin-2 antibody; Endothelial sialomucin antibody; Gastric cancer antigen Ga34 antibody; MUC-14 antibody; MUC14 antibody; MUCEN_HUMAN antibody; Mucin 14 antibody; Mucin-14 antibody
Raised in
Species Reactivity
Recombinant Human Endomucin protein (19-135AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Rabbits were immunized with the recombinant human Endomucin protein (19-135aa) to produce the EMCN polyclonal antibodies. This stimulates the rabbit's immune system to produce a varied set of antibodies that recognize distinct epitopes on the antigen. Subsequently, the antibodies were purified from the rabbits' sera using antigen affinity chromatography.

The effectiveness of the EMCN antibody was evaluated in ELISA and IHC applications, and it was found to efficiently identify and bind the EMCN protein in human samples. The EMCN protein is involved in controlling vascular permeability and angiogenesis, which is the process of forming new blood vessels.

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Target Background

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
Gene References into Functions
  1. In contrast, endomucin (EMCN) is present on the lymphatic sinus endothelium and not on lymphatic endothelium of the subcapsular sinus. Moreover, both murine and human MSR1 on lymphatic endothelium of the SS bind lymphocytes and in in vivo studies MSR1 regulates entrance of lymphocytes from the SS to the lymph node parenchyma PMID: 27601677
  2. These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues. PMID: 26831939
  3. Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation. PMID: 21666600
  4. A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis. PMID: 21159824
Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.; [Isoform 2]: Secreted.
Tissue Specificity
Expressed in heart, kidney and lung.
Database Links

HGNC: 16041

OMIM: 608350

KEGG: hsa:51705

STRING: 9606.ENSP00000296420

UniGene: Hs.152913

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