EPHA1 Antibody

1. EphA1 expression is decreased in ovarian serous carcinoma compared with normal fallopian tube and benign ovarian serous cystadenoma. Decreased EphA1 expression was more often detected in high-grade tumors. PMID: 29393455
2. Results show that EPHA1 expression is up-regulated in ovarian cancer (OC) cells and provide evidence that it may promote the aggression of some OC cells. PMID: 28739735
3. EPHA1 suppresses spreading and adhesion of HRT18 colorectal cancer cells through deactivation of ERK and JNK signaling pathways. PMID: 26977017
4. Data indicate that EphA1 protein may be a new marker for the prognosis of clear cell renal cell carcinoma. PMID: 26261568
5. High expression of EphA1 was associated with metastasis and recurrence in Gastric Cancer. PMID: 25391265
6. This study suggests EPHA1 (rs11771145) interferes with the pathological alteration of the hippocampus and the lateral occipitotemporal and inferior temporal gyri throughout the Alzheimer's disease process, leading to a lower risk of Alzheimer's disease. PMID: 25182741
7. EphrinA1 plays an important role in the TNF-alpha-mediated adhesion of monocytes to endothelial cells. PMID: 25451169
8. Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma. PMID: 25025847
9. two states of the EphA1 transmembrane helix dimer PMID: 25286141
10. Suggest EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer. PMID: 24040450
11. High Eph A1 expression is associated with choriocarcinoma invasion. PMID: 23429488
12. Results show that EphA1 appears to be a differentiation marker for esophageal squamous cells, and its increased expression is positively associated with lymph node metastasis and advanced disease stage. PMID: 23030051
13. EphrinA1 is released in three forms from cancer cells by matrix metalloproteases PMID: 22688511
14. The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer. PMID: 21503576
15. found independent evidence for association for Alzheimer's disease susceptibility loci at EPHA1, CD33 and CD2AP PMID: 21460840
16. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. PMID: 21460841
17. The EphA1 expression level is a potential prognostic marker in gastric carcinoma, and may provide a novel target of therapy for gastric carcinoma. PMID: 21042754
18. Eph-A1 staining intensity was significantly associated with tumor size and tumor histopathological stage in pancreatic ductal adenocarcinoma PMID: 19949912
19. Suppression of EphA1 expression in Huh-7 cells reduced their outgrowth when inoculated in the subcutaneous space in the flank of nude mice, presumably through angiogenesis inhibition since microvessel density was found to be inhibited. PMID: 20043122
20. EphA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. PMID: 16862074
21. I 12 acquired a higher affinity toward EphA2 with K(d) 18 nm and inhibited vascular endothelial growth factor-dependent angiogenic invasion in a Matrigel plug assay PMID: 18308734
22. Results suggest that EphA1-receptor transmembrane domains contribute to the dimerization-mediated receptor activation. PMID: 18590698
23. analysis of the spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 PMID: 18728013
24. In EphA1 null transgenic mice a possible role for EphA1 in tissue patterning and hormone-induced apoptotic processes is indicated. PMID: 18802966
25. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. PMID: 18990944
26. EphA1 may play different roles during the different stages of colorectal carcinoma progression. PMID: 19011600
27. EphA1 regulates cell morphology and motility through the ILK-RhoA-ROCK pathway. PMID: 19118217
28. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. PMID: 19277044

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HGNC: 3385

OMIM: 179610

KEGG: hsa:2041

STRING: 9606.ENSP00000275815

UniGene: Hs.89839