EPHA1 Antibody, Biotin conjugated

1. EphA1 expression is decreased in ovarian serous carcinoma compared with normal fallopian tube and benign ovarian serous cystadenoma. Decreased EphA1 expression was more often detected in high-grade tumors. PMID: 29393455
2. Results show that EPHA1 expression is up-regulated in ovarian cancer (OC) cells and provide evidence that it may promote the aggression of some OC cells. PMID: 28739735
3. EPHA1 suppresses spreading and adhesion of HRT18 colorectal cancer cells through deactivation of ERK and JNK signaling pathways. PMID: 26977017
4. Data indicate that EphA1 protein may be a new marker for the prognosis of clear cell renal cell carcinoma. PMID: 26261568
5. High expression of EphA1 was associated with metastasis and recurrence in Gastric Cancer. PMID: 25391265
6. This study suggests EPHA1 (rs11771145) interferes with the pathological alteration of the hippocampus and the lateral occipitotemporal and inferior temporal gyri throughout the Alzheimer's disease process, leading to a lower risk of Alzheimer's disease. PMID: 25182741
7. EphrinA1 plays an important role in the TNF-alpha-mediated adhesion of monocytes to endothelial cells. PMID: 25451169
8. Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma. PMID: 25025847
9. two states of the EphA1 transmembrane helix dimer PMID: 25286141
10. Suggest EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer. PMID: 24040450
11. High Eph A1 expression is associated with choriocarcinoma invasion. PMID: 23429488
12. Results show that EphA1 appears to be a differentiation marker for esophageal squamous cells, and its increased expression is positively associated with lymph node metastasis and advanced disease stage. PMID: 23030051
13. EphrinA1 is released in three forms from cancer cells by matrix metalloproteases PMID: 22688511
14. The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer. PMID: 21503576
15. found independent evidence for association for Alzheimer's disease susceptibility loci at EPHA1, CD33 and CD2AP PMID: 21460840
16. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. PMID: 21460841
17. The EphA1 expression level is a potential prognostic marker in gastric carcinoma, and may provide a novel target of therapy for gastric carcinoma. PMID: 21042754
18. Eph-A1 staining intensity was significantly associated with tumor size and tumor histopathological stage in pancreatic ductal adenocarcinoma PMID: 19949912
19. Suppression of EphA1 expression in Huh-7 cells reduced their outgrowth when inoculated in the subcutaneous space in the flank of nude mice, presumably through angiogenesis inhibition since microvessel density was found to be inhibited. PMID: 20043122
20. EphA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. PMID: 16862074
21. I 12 acquired a higher affinity toward EphA2 with K(d) 18 nm and inhibited vascular endothelial growth factor-dependent angiogenic invasion in a Matrigel plug assay PMID: 18308734
22. Results suggest that EphA1-receptor transmembrane domains contribute to the dimerization-mediated receptor activation. PMID: 18590698
23. analysis of the spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 PMID: 18728013
24. In EphA1 null transgenic mice a possible role for EphA1 in tissue patterning and hormone-induced apoptotic processes is indicated. PMID: 18802966
25. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. PMID: 18990944
26. EphA1 may play different roles during the different stages of colorectal carcinoma progression. PMID: 19011600
27. EphA1 regulates cell morphology and motility through the ILK-RhoA-ROCK pathway. PMID: 19118217
28. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. PMID: 19277044

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HGNC: 3385

OMIM: 179610

KEGG: hsa:2041

STRING: 9606.ENSP00000275815

UniGene: Hs.89839