EPHA1

The protein encoded by EPHA1 is Ephrin type-A receptor 1, a member of the Eph receptor tyrosine kinase family. Common aliases include EPH receptor A1 and EPHT1. It functions as a cell surface receptor, mediating cell-cell communication through interaction with ephrin-A ligands, leading to bidirectional signaling that regulates cell adhesion, migration, and axon guidance.
EPHA1 is involved in the Eph-ephrin signaling pathway, playing roles in embryonic development and tissue homeostasis. Dysregulation is associated with various cancers, including breast and prostate cancer, where it may promote tumor angiogenesis and metastasis. Current drug focuses on small-molecule inhibitors targeting its kinase activity, though clinical development is in early stages with preclinical studies investigating efficacy in solid tumors.