EPN3 Antibody

Code CSB-PA243224
Size US$297
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  • Western blot analysis of extracts from K562 cells, using EPN3 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using EPN3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EPN3 Polyclonal antibody
Uniprot No.
Target Names
EPN3
Alternative Names
EPN 3 antibody; Epn3 antibody; EPN3_HUMAN antibody; EPS 15 interacting protein 3 antibody; EPS-15-interacting protein 3 antibody; Epsin 3 antibody; Epsin-3 antibody; Epsin3 antibody; FLJ20778 antibody; MGC129899 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human EPN3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. These results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/betacatenin signaling pathways may contribute to this process. PMID: 30226603
  2. High expression of epsin (EPN3) was associated with increased risk of late metastasis. PMID: 27926932
Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus.
Protein Families
Epsin family
Tissue Specificity
Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis.
Database Links

HGNC: 18235

OMIM: 607264

KEGG: hsa:55040

STRING: 9606.ENSP00000268933

UniGene: Hs.670090

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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