ESX1 Antibody

Code CSB-PA007838GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ESX1
Alternative Names
ESX1 antibody; ESX1L antibody; ESX1R antibody; Homeobox protein ESX1 antibody; Extraembryonic antibody; spermatogenesis antibody; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C] antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human ESX1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Gene References into Functions
  1. ESX1 mRNA level decreases as the severity of spermatogenic defects increase in non-obstructive azoospermic men. PMID: 25316452
  2. ESX1 emerges as a potentially reliable molecular marker of residual spermatogenesis in azoospermic men PMID: 20356899
  3. proteolytic processing of ESXR1 plays a role in concerted regulation of the cell cycle and transcription in human cells PMID: 15235584
  4. ESX1L is expressed during all stages of placental development and is localized to sparse areas of trophoblast in terminal villi in association with cytotrophoblastic cells PMID: 15601583
  5. In FGR-affected placentae, ESX1L levels were lower than in gestation-matched controls, indicating a potential role for the ESX1L gene within the growth control mechanism of the fetus, through its effect on placental function. PMID: 16613891

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Subcellular Location
Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue Specificity
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Database Links

HGNC: 14865

OMIM: 300154

KEGG: hsa:80712

STRING: 9606.ENSP00000361669

UniGene: Hs.223782

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