FADS1 Antibody

Datasheet
Code CSB-PA007959LA01HU
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Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O60427
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007959LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA007959LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA007959LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Western Blot
    Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate
    All lanes: FADS1 antibody at 3.4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 52, 43 kDa
    Observed band size: 52 kDa

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Fatty acid desaturase 1 protein (1-121AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Relevance Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase), FADS1, FADSD5
Immunogen Species Human
Research Area Tags & Cell Markers
Target Names FADS1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Isoform 2 does not exhibit any catalytic activity toward 20
Subcellular Location Isoform 1: Endoplasmic reticulum membrane, Multi-pass membrane protein, Mitochondrion, SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families Fatty acid desaturase type 1 family
Tissue Specificity Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
Database Links

HGNC: 3574

OMIM: 606148

KEGG: hsa:3992

STRING: 9606.ENSP00000322229

UniGene: Hs.503546

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