FBP2 Antibody

Datasheet

Code	CSB-PA008460LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: MCF-7 whole cell lysate, Rat skeletal muscle tissue All lanes: FBP2 antibody at 3.5μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 37 kDa Observed band size: 37 kDa Immunofluorescence staining of HepG2 cells with CSB-PA008460LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FBP2 Polyclonal antibody

Uniprot No.

O00757

Target Names

FBP2

Alternative Names

6-bisphosphatase isozyme 2 antibody; 6-bisphosphate 1-phosphohydrolase 2 antibody; D fructose 1 6 bisphosphate 1 phosphohydrolase 2 antibody; D-fructose-1 antibody; F16P2_HUMAN antibody; FBP 2 antibody; fbp2 antibody; FBPase 2 antibody; FBPase antibody; fructose 1 6 bisphosphatase 2 antibody; Fructose 1 6 bisphosphatase isozyme 2 antibody; Fructose-1 antibody; Hexosediphosphatase antibody; MGC142192 antibody; Muscle FBPase antibody; Muscle fructose bisphosphatase antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Fructose-1,6-bisphosphatase isozyme 2 protein (283-339AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FBP2 Antibody (Product code: CSB-PA008460LA01HU) is Non-conjugated. For FBP2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA008460LB01HU	FBP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008460LC01HU	FBP2 Antibody, FITC conjugated
Biotin	CSB-PA008460LD01HU	FBP2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

Gene References into Functions

Results demonstrate that truncation of the evolutionarily conserved N-terminal residues of FBP2 results in a loss of its mitochondria-protective functions. PMID: 24412565
FBP2 does negatively regulate cell growth, and reduced expression of FBP2 may contribute to carcinogenesis for gastric cancer. PMID: 24063558
The key role in strong AMP binding to muscle isozyme play K20, T177 and Q179. PMID: 16213487
The existence of highly AMP-sensitive muscle-like FBPase, activity of which is regulated by metabolite-dependent interaction with aldolase enables the precise regulation of muscle energy expenditures. PMID: 18214967

Subcellular Location

Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.

Protein Families

FBPase class 1 family

Tissue Specificity

Expressed in skeletal muscle (at protein level).

Database Links

HGNC: 3607

OMIM: 603027

KEGG: hsa:8789

STRING: 9606.ENSP00000364486

UniGene: Hs.61255

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Related pathways

AMPK signaling Insulin signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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