FBXO4 Antibody

Code CSB-PA891538ESR1HU
Size US$166
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  • Western blot
    All lanes: FBXO4 antibody at 3.1μg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: HepG2 whole cell lysate
    Lane 3: HL60 whole cell lysate
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 45, 36 kDa
    Observed band size: 45 kDa

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA891538ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA891538ESR1HU at dilution of 1:100

  • Immunoprecipitating FBXO4 in HepG2 whole cell lysate
    Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA891538ESR1HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
    Lane 2: CSB-PA891538ESR1HU (4µg) + HepG2 whole cell lysate (500µg)
    Lane 3: HepG2 whole cell lysate (20µg)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXO4 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
DKFZp547N213 antibody; F box only protein 4 antibody; F box protein 4 antibody; F box protein Fbx4 antibody; F-box only protein 4 antibody; FBX4 antibody; FBX4_HUMAN antibody; FBXO 4 antibody; FBXO4 antibody; FLJ10141 antibody
Raised in
Species Reactivity
Recombinant Human F-box only protein 4 protein (138-387AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IP 1:200-1:2000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
Gene References into Functions
  1. in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1) overexpression correlates with reduced F-box protein 4 (Fbxo4) levels. PMID: 29142209
  2. FBXO4 is the E3 ubiquitin ligase to interact with and promote Mcl-1 ubiquitination and degradation. PMID: 28776569
  3. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 expression in human cancers. PMID: 24704453
  4. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation. PMID: 24019069
  5. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function. PMID: 21242966
  6. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein. PMID: 20181953
  7. results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control PMID: 20159592
  8. Fbx4 is a central regulator of Pin2/TRF1 protein abundance and alterations in the stability of Pin2/TRF1 can have a dramatic impact on telomere length PMID: 16275645
  9. SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1. PMID: 17081987
  10. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. PMID: 18598945

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Subcellular Location
Database Links

HGNC: 13583

OMIM: 609090

KEGG: hsa:26272

STRING: 9606.ENSP00000281623

UniGene: Hs.165575

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