FEN1 Antibody, Biotin conjugated

Code CSB-PA008585LD01DOA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) FEN1 Polyclonal antibody
Uniprot No.
Target Names
FEN1
Alternative Names
FEN1 antibody; At5g26680 antibody; F21E10.3Flap endonuclease 1 antibody; FEN-1 antibody; EC 3.1.-.- antibody; Flap structure-specific endonuclease 1 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana Flap endonuclease 1 protein (85-383AA)
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Gene References into Functions
  1. At5g26680 role in mediating transcriptional gene silencing as well as maintaining genome stability PMID: 27231839
  2. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity. PMID: 26721386
Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion.
Protein Families
XPG/RAD2 endonuclease family, FEN1 subfamily
Database Links

KEGG: ath:AT5G26680

STRING: 3702.AT5G26680.1

UniGene: At.47103

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