FEN1 Antibody, FITC conjugated

Datasheet
Code CSB-PA008585LC01DOA
Size US$299
Uniprot No. O65251
Protocols ELISA Protocol
Immunogen Recombinant Arabidopsis thaliana Flap endonuclease 1 protein (85-383AA)
Raised in Rabbit
Species Reactivity Arabidopsis thaliana
Tested Applications ELISA
Relevance Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinicapyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1, FEN1
Immunogen Species Arabidopsis thaliana (Mouse-ear cress)
Research Area Epigenetics and Nuclear Signaling
Target Names FEN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Subcellular Location Nucleus, nucleolus, Nucleus, nucleoplasm, Mitochondrion
Protein Families XPG/RAD2 endonuclease family, FEN1 subfamily
Database Links

KEGG: ath:AT5G26680

STRING: 3702.AT5G26680.1

UniGene: At.47103

Pathway DNA repair pathway

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