FKBP10 Antibody

1. FKBP10 interacts with collagen VI and deficiency of FKBP10 reduces lung fibroblast migration by down-regulation of collage VI synthesis. PMID: 29673351
2. Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta PMID: 29512769
3. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
4. FKBP10 protein is overexpressed in renal cell carcinoma PMID: 27602571
5. FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2. PMID: 27298363
6. novel pathogenic mutations of FKBP10 can lead to the extremely rare type XI Osteogenesis imperfecta without contractures, which expands the genotypic spectrum of Osteogenesis imperfecta. PMID: 27762305
7. Mutations in FKBP10, localised to chromosome 17q21, have been identified in a patient of Bruck syndrome. Additional cases are also discussed. PMID: 25931047
8. A pathogenic change was found in the FKBP10 gene in patients with osteogenesis imperfecta. PMID: 27706701
9. findings further extend the body of evidence that supports the importance of FKBP10 gene in the development of skeletal system PMID: 26538303
10. Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect. PMID: 25510505
11. CTSD, FKBP10, and SLC2A1 are novel genes that participate in the acquisition and maintenance of the adriamycin-resistant phenotype in leukemia cells. PMID: 24467213
12. Results imply that FKBP10 mutations affect collagen indirectly, by ablating FKBP65 support for collagen telopeptide hydroxylation by lysyl hydroxylase 2, thus decreasing collagen cross-links in tendon and bone matrix. PMID: 23712425
13. Elastin binding protein and FKBP65 modulate the kinetics of self-assembly of tropoelastin in an in vitro system. PMID: 24106871
14. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts PMID: 23434032
15. underexpression of FKBP65 protein is characteristic of high-grade serous carcinomas and this expression profile may be linked to molecular pathways associated with an unfavourable outcome in cancer patients. PMID: 23354471
16. FKBP10 acts during procollagen maturation to contribute to molecular stability and post-translational modification of type I procollagen, without which bone mass and quality are abnormal and fractures and contractures result PMID: 22949511
17. identified a Palestinian pedigree with moderate and lethal forms of recessive OI caused by mutations in FKBP10 or PPIB, which encode endoplasmic reticulum resident chaperone/isomerases FKBP65 and CyPB, respectively PMID: 22718341
18. Homozygosity mapping identified FKBP10 as a candidate gene, and sequencing revealed a base pair exchange that causes a C-terminal premature stop codon in this gene. PMID: 22107750
19. Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. PMID: 21567934
20. The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development PMID: 21399973
21. FKBP10 mutations are a cause of recessive osteogenesis imperfecta and Bruck syndrome. PMID: 20839288
22. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. PMID: 20362275

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HGNC: 18169

OMIM: 259450

KEGG: hsa:60681

STRING: 9606.ENSP00000317232

UniGene: Hs.463035