FTO Antibody

Datasheet
Code CSB-PA004640
Size US$167
Uniprot No. Q9C0B1
Image
  • Western Blot analysis of K562 cells using FTO Polyclonal Antibody
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from the N-terminal region of Human FTO.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein
Immunogen Species Homo sapiens (Human)
Target Names FTO
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
References
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Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine
Involvement in disease Growth retardation, developmental delay, and facial dysmorphism (GDFD); Obesity (OBESITY)
Subcellular Location Nucleus, Nucleus speckle
Protein Families Fto family
Tissue Specificity Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
Database Links

HGNC: 24678

OMIM: 601665

KEGG: hsa:79068

STRING: 9606.ENSP00000418823

UniGene: Hs.528833

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