FUNDC1 Antibody, HRP conjugated

Code CSB-PA816886LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FUNDC1 Polyclonal antibody
Uniprot No.
Target Names
FUNDC1
Alternative Names
FUNDC1; FUN14 domain-containing protein 1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human FUN14 domain-containing protein 1 protein (1-46AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Gene References into Functions
  1. Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy. PMID: 28719148
  2. phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy. PMID: 27653272
  3. FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells. PMID: 27145933
  4. FUNDC1 regulates both mitochondrial fission or fusion and mitophagy. PMID: 27050458
  5. The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy. PMID: 25126723
  6. FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy. PMID: 24671035
  7. Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1. PMID: 22267086

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Subcellular Location
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein Families
FUN14 family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 28746

OMIM: 300871

KEGG: hsa:139341

STRING: 9606.ENSP00000367284

UniGene: Hs.7549

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