FUT8 Antibody

Code CSB-PA887159LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: Mouse liver tissue
    All lanes: FUT8 antibody at 5.9μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 67, 36, 48, 20 kDa
    Observed band size: 48 kDa

  • IHC image of CSB-PA887159LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FUT8 Polyclonal antibody
Uniprot No.
Target Names
FUT8
Alternative Names
6-fucosyltransferase antibody; Alpha (1,6) fucosyltransferase antibody; Alpha-(1,6)-fucosyltransferase antibody; Alpha1 6FucT antibody; alpha1-6FucT antibody; Fucosyltransferase 8 (alpha (1,6) fucosyltransferase) antibody; Fucosyltransferase 8 antibody; FUT8 antibody; FUT8_HUMAN antibody; GDP fucose glycoprotein fucosyltransferase antibody; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase antibody; GDP-fucose--glycoprotein fucosyltransferase antibody; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1 antibody; Glycoprotein 6 alpha L fucosyltransferase antibody; Glycoprotein 6-alpha-L-fucosyltransferase antibody; MGC26465 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Alpha-(1,6)-fucosyltransferase protein (247-377AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FUT8 Antibody (Product code: CSB-PA887159LA01HU) is Non-conjugated. For FUT8 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA887159LB01HU FUT8 Antibody, HRP conjugated ELISA
FITC CSB-PA887159LC01HU FUT8 Antibody, FITC conjugated
Biotin CSB-PA887159LD01HU FUT8 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
Gene References into Functions
  1. loss of function mutations in FUT8 cause a congenital disorder of glycosylation (FUT8-CDG) characterized by defective core fucosylation. PMID: 29304374
  2. we also demonstrated that overexpression of FUT8 might be responsible for the decreased PSA expression in prostate cancer specimens. To our knowledge, this is the first study reporting the functional role of fucosylated enzyme in the development of castration-resistant prostate cancer. PMID: 29339807
  3. This study thus provides insights into the interplay among FUT8, N-acetylglucosaminyltransferase , and GnT-V in N-linked glycosylation during the assembly of glycoproteins. PMID: 28678517
  4. Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-b signaling and EMT, thus stimulating breast cancer cell invasion and metastasis. PMID: 28982386
  5. FUT8 is regulated by microRNAs and has a role in hepatocellular carcinoma progression PMID: 27533464
  6. We observed a strong correlation between EVI1 and alpha1, 6-fucosyltransferase (FUT8) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease. PMID: 27967290
  7. This study demonstrated that the alteration of FTU8 expression in the superior temporal gyrus of elderly patients with schizophrenia. PMID: 27773385
  8. results suggest that an appropriate polypeptide context or other adequate structural elements in the acceptor substrate could facilitate the core fucosylation by FUT8 PMID: 28729420
  9. FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination. PMID: 28609658
  10. The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO in the FUT8-overexpressed HEK293S GnT I(-/-) cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms. PMID: 27008861
  11. Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients PMID: 26596733
  12. MiR-198 was shown to target the 3'UTR of FUT8 directly to downregulate FUT8 expression. PMID: 25174450
  13. High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. PMID: 25572677
  14. Our results suggest that FUT8 may be associated with aggressive PCa and thus is potentially useful for its prognosis. PMID: 24906821
  15. miR-122 and miR-34a are able to target FUT8 3'UTR PMID: 24130780
  16. alpha 1,6-fucosyltransferase 8 expression might be a good indicator of poor prognosis in hepatocellular carcinoma. High alpha 1,6-fucosyltransferase 8 expression may play an important role in hepatitis B virus-related hepatocellular carcinoma progression PMID: 23352314
  17. findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation PMID: 23609441
  18. The FUT8 gene Thr267Lys polymorphism is associated with human pulmonary emphysema (PE). PMID: 22011814
  19. in colorectal carcinoma patients with moderate or strong alpha(1,6)fucosyltransferase expression, a significant decrease in the overall (P = .04) and disease-free (P = .03) survival rates was observed PMID: 21652057
  20. Expression of FUT8 is regulated by three different promoters, starting transcription in exons A, B, or C. PMID: 14514715
  21. These results suggest that FUT8 expression may be a key factor in the progression of thyroid papillary carcinomas, but not follicular carcinomas, and decreases in FUT8 expression might be linked to anaplastic transformation. PMID: 14568171
  22. We investigated mRNA levels of glycosyltransferases, namely N-acetylglucosaminyltransferase a (GnT)-IVb, and found that (GnT)-IVb expression was increased in HLE-cells resistant to Epirubicin PMID: 17488527
  23. Vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 expression. PMID: 19179362

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Subcellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 23 family
Database Links

HGNC: 4019

OMIM: 602589

KEGG: hsa:2530

STRING: 9606.ENSP00000353910

UniGene: Hs.597649

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