FUT8

FUT8 encodes the alpha-1,6-fucosyltransferase protein, also known as FucT-VIII. This enzyme is crucial for adding an alpha-1,6-fucose residue to the innermost N-acetylglucosamine of N -linked glycans. It functions within the Golgi apparatus. The fucosylation process mediated by FUT8 is involved in various signaling pathways, including the EGFR and TGF -β pathways.
Aberrant FUT8 activity is associated with several diseases such as cancer, where it can promote tumor cell growth, invasion, and metastasis. In the field of drug development, inhibitors targeting FUT8 are being explored for their potential in cancer treatment, aiming to disrupt the abnormal fucosylation and associated signaling pathways.