Fcmr Antibody, FITC conjugated

Datasheet

Code	CSB-PA007972LC01MO
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Fcmr Polyclonal antibody

Uniprot No.

A1KXC4

Target Names

Fcmr

Alternative Names

Fcmr antibody; Faim3 antibody; TosoFas apoptotic inhibitory molecule 3 antibody; IgM Fc fragment receptor antibody; Regulator of Fas-induced apoptosis Toso antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Fas apoptotic inhibitory molecule 3 protein (18-262AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Gene References into Functions

Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection. PMID: 25257173
these findings suggest that FcmuR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr) mice. PMID: 24994818
FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge. PMID: 23267023
Toso is a unique regulator of inflammatory autoimmune responses with a protective role against experimental autoimmune encephalomyelitis PMID: 24398517
Toso is a unique regulator of innate immune responses during bacterial infection and septic shock. PMID: 23359703
These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis. PMID: 15632112

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Subcellular Location

Membrane; Single-pass membrane protein.

Database Links

KEGG: mmu:69169

STRING: 10090.ENSMUSP00000048303

UniGene: Mm.46042

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