Fcmr Antibody

Code CSB-PA007972LA01MO
Size US$166
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Image
  • Western blot
    All lanes: Fcmr antibody at 2µg/ml
    Lane 1: Rat spleen tissue
    Lane 2: Rat kidney tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 48 kDa
    Observed band size: 48 kDa
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Fcmr Polyclonal antibody
Uniprot No.
Target Names
Fcmr
Alternative Names
Fcmr antibody; Faim3 antibody; TosoFas apoptotic inhibitory molecule 3 antibody; IgM Fc fragment receptor antibody; Regulator of Fas-induced apoptosis Toso antibody
Raised in
Rabbit
Species Reactivity
Mouse, Rat
Immunogen
Recombinant Mouse Fas apoptotic inhibitory molecule 3 protein (18-262AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Fcmr Antibody (Product code: CSB-PA007972LA01MO) is Non-conjugated. For Fcmr Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007972LB01MO Fcmr Antibody, HRP conjugated ELISA
FITC CSB-PA007972LC01MO Fcmr Antibody, FITC conjugated
Biotin CSB-PA007972LD01MO Fcmr Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Gene References into Functions
  1. Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection. PMID: 25257173
  2. these findings suggest that FcmuR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr) mice. PMID: 24994818
  3. FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge. PMID: 23267023
  4. Toso is a unique regulator of inflammatory autoimmune responses with a protective role against experimental autoimmune encephalomyelitis PMID: 24398517
  5. Toso is a unique regulator of innate immune responses during bacterial infection and septic shock. PMID: 23359703
  6. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
  7. mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis. PMID: 15632112

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Subcellular Location
Membrane; Single-pass membrane protein.
Database Links
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