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Phospho-mFLNc (S2237) Antibody

Datasheet
Code CSB-PA837745XA01phMO
Size US$166
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Product Details

Uniprot No.
Q8VHX6
Target Names
Flnc
Alternative Names
Filamin-C, FLN-C, ABP-280-like protein, ABP-L, Actin-binding-like protein, Filamin-2, Gamma-filamin, Flnc, Abpl, Fln2
Species Reactivity
Mus musculus (Mouse)
Immunogen
Synthesized peptide derived from Mouse FLNc around the phosphorylation site of S2237.
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Affinity-purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

Flnc Proteins

Customer Reviews and Q&A

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■ Q&A
Q:

I want the following of the two antibodies produced:
mouse FLNc (mFLNc) phosphorylated at S2237
human FLNc (hFLNc) phosphorylated at S2236
These are mouse and human orthologs of the same phosphorylated residues.

A:

Cusabio can offer a Custom Polyclonal Antibody Production in rabbits to generate the antibodies against mouse FLNc (mFLNc) phosphorylated at S2237 and human FLNc (hFLNc) phosphorylated at S2236. Our standard rabbit immunization protocol for this polyclonal antibody production will take 80-100 business days.

The Deliverables and Guarantee of our standard rabbit polyclonal antibody production protocol include:
Quality guarantee:
1. Peptide purity >85% by HPLC
2. Antibody purity > 90% confirmed by SDS-PAGE;
3. Antibody titer > 1: 64,000 confirmed by ELISA;
Deliverables:
1. 200ug peptide-KHL/BSA conjugate.
2. 1ml preimmune serum.
3. 1mg rabbit polyclonal antibody purified by peptide affinity chromatography.

Target Background

Function
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Gene References into Functions
  1. HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC PMID: 26929074
  2. The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. PMID: 26555887
  3. Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. PMID: 24963132
  4. KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. PMID: 20206623
  5. filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population PMID: 15910244
  6. These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. PMID: 16914736
  7. MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
  8. Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity PMID: 17898075

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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
Protein Families
Filamin family
Database Links
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Related pathways
MAPK signaling pathway Focal adhesion
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