Name: Phospho-mFLNc (S2237) Antibody
Brand: CUSABIO
SKU: CSB-PA837745XA01phMO

Product Details

Uniprot No.

Q8VHX6

Target Names

Flnc

Alternative Names

Filamin-C, FLN-C, ABP-280-like protein, ABP-L, Actin-binding-like protein, Filamin-2, Gamma-filamin, Flnc, Abpl, Fln2

Species Reactivity

Mus musculus (Mouse)

Immunogen

Synthesized peptide derived from Mouse FLNc around the phosphorylation site of S2237.

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

I want the following of the two antibodies produced:
mouse FLNc (mFLNc) phosphorylated at S2237
human FLNc (hFLNc) phosphorylated at S2236
These are mouse and human orthologs of the same phosphorylated residues.

Cusabio can offer a Custom Polyclonal Antibody Production in rabbits to generate the antibodies against mouse FLNc (mFLNc) phosphorylated at S2237 and human FLNc (hFLNc) phosphorylated at S2236. Our standard rabbit immunization protocol for this polyclonal antibody production will take 80-100 business days.

The Deliverables and Guarantee of our standard rabbit polyclonal antibody production protocol include:
Quality guarantee:
1. Peptide purity >85% by HPLC
2. Antibody purity > 90% confirmed by SDS-PAGE;
3. Antibody titer > 1: 64,000 confirmed by ELISA;
Deliverables:
1. 200ug peptide-KHL/BSA conjugate.
2. 1ml preimmune serum.
3. 1mg rabbit polyclonal antibody purified by peptide affinity chromatography.

Target Background

Function

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.

Gene References into Functions

HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC PMID: 26929074
The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. PMID: 26555887
Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. PMID: 24963132
KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. PMID: 20206623
filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population PMID: 15910244
These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. PMID: 16914736
MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity PMID: 17898075

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Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.

Protein Families

Filamin family

Database Links

KEGG: mmu:68794

STRING: 10090.ENSMUSP00000087960

UniGene: Mm.39046

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Phospho-mFLNc (S2237) Antibody

Product Details

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Customer Reviews and Q&A

Target Background