Name: Recombinant Mouse Filamin-C (Flnc), partial
Brand: CUSABIO
SKU: 837745MO

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Flnc

Uniprot No.

Q8VHX6

Alternative Names

Flnc; Abpl; Fln2Filamin-C; FLN-C; ABP-280-like protein; ABP-L; Actin-binding-like protein; Filamin-2; Gamma-filamin

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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■ Q&A

Could you please provide sequence, availability and tag information for all available sizes?
Have you received any customer feedback about the activity of this protein?

Thanks for your inquiry.
Recombinant Mouse Filamin-C(Flnc),partial
CSB-YP837745MO >> Yeast
Expression Region: 1-263aa; Partial, including the Calponin-homology (CH) 1 Domain and Calponin-homology (CH) 2 Domain
Tag information:Tag type will be determined during the manufacturing process.
The expected tag is N-terminal 6xHis-tagged.
Sequence:

MMNNSNYSDASGLGLVDEADEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVQNAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKL

Sorry, as this is a semi-custom protein, which means we have never expressed this protein before, so also haven't tested the activity, we can't 100% guarantee its activity.However, as we adpot Affinity chromatography purification, it's purified under very mild condition, it should be active, we recommend you to purchase a small size to have a try.
Reference: http://europepmc.org/articles/PMC3113346

Target Background

Function

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.

Gene References into Functions

HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC PMID: 26929074
The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. PMID: 26555887
Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. PMID: 24963132
KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. PMID: 20206623
filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population PMID: 15910244
These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. PMID: 16914736
MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity PMID: 17898075

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Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.

Protein Families

Filamin family

Database Links

KEGG: mmu:68794

STRING: 10090.ENSMUSP00000087960

UniGene: Mm.39046

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Recombinant Mouse Filamin-C (Flnc), partial

Product Details

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Target Background

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