FLNC

Filamin C (FLNC), encoded by the FLNC gene, is a muscle-specific actin-binding protein also known as ABP-280 homolog in muscle. It cross-links actin filaments at sarcomeric Z-discs, maintaining cytoskeletal integrity and transmitting mechanical forces in striated muscle. It interacts with dystrophin, participating in the dystrophin-glycoprotein complex pathway to stabilize muscle cells.
FLNC mutations cause neuromuscular disorders like limb-girdle muscular dystrophy, dilated cardiomyopathy, and myofibrillar myopathy. Drug development is early: CRISPR-based gene editing to correct mutations is being explored, while small molecules targeting protein misfolding are in preclinical studies—no approved therapies exist yet.