GFRA4 Antibody

Code CSB-PA050010
Size US$100
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Product Details

Uniprot No.
Target Names
GFRA4
Alternative Names
GDNF family receptor alpha 4 antibody; GDNF family receptor alpha-4 antibody; GDNF receptor alpha-4 antibody; GDNFR-alpha-4 antibody; GFR alpha 4 antibody; GFR receptor alpha 4 antibody; GFR-alpha-4 antibody; GFRA4 antibody; GFRA4_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha 4 antibody; Neurotrophic factor receptor splice variant A (Gfra4 gene) antibody; OTTHUMP00000030106 antibody; OTTHUMP00000030107 antibody; Persephin receptor antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human GFRα-4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Gene References into Functions
  1. Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system. PMID: 29634418
  2. High GFRA4 expression is associated with Hirschsprung's Disease. PMID: 29090971
  3. GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts. PMID: 15225646
Subcellular Location
[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
Protein Families
GDNFR family
Tissue Specificity
Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
Database Links

HGNC: 13821

KEGG: hsa:64096

STRING: 9606.ENSP00000313423

UniGene: Hs.302025

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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