GFRA4

GFRA4, also known as GDNF family receptor alpha 4 or persephin receptor, is a glycosylphosphatidylinositol-linked cell surface receptor. It mediates the activation of the RET tyrosine kinase receptor, playing a crucial role in neural development and cell survival. GFRA4 is involved in various signaling pathways, including the RET signaling pathway and the hedgehog pathway. Diseases associated with GFRA4 include Hirschsprung disease and thyroid carcinoma. Drug development for GFRA4 targets involves modulators that can either activate or inhibit the receptor, aiming to treat diseases like cancer and neurodegenerative disorders.