GK Antibody, HRP conjugated

Code CSB-PA300097LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GK Polyclonal antibody
Uniprot No.
Target Names
GK
Alternative Names
ATP glycerol 3 phosphotransferase antibody; ATP:glycerol 3 phosphotransferase antibody; ATP:glycerol 3-phosphotransferase antibody; D930012N15Rik antibody; GK antibody; GK1 antibody; GKD antibody; GLPK_HUMAN antibody; Glycerokinase antibody; Glycerol kinase antibody; OTTHUMP00000023108 antibody; OTTHUMP00000023109 antibody; OTTHUMP00000215321 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Glycerol kinase protein (346-509AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Key enzyme in the regulation of glycerol uptake and metabolism.
Gene References into Functions
  1. Both patients were found to have Xp21.2 deletions involving all coding seqeunces of the glycerol kinase (GK) gene. PMID: 27087023
  2. Two siblings with the contiguous X-linked gene deletion syndrome, complex glycerol kinase deficiency, are described. The elder sibling demonstrates the difficulties diagnosing this rare condition. PMID: 20110216
  3. missense mutations and deletions in glycerol kinase is associated with persistent hypertriglyceridemia PMID: 12636049
  4. a functional HNF-4alpha binding site in the first 500 bp of the 5(') upstream region is important for increased levels of glycerol kinase expression PMID: 14654354
  5. Comparison of expression patterns, as well as enzymatic characteristics and subcellular localization of alternatively spliced glycerol kinase isoforms. PMID: 15845384
  6. Results suggest that influences on RNA processing and protein stability represent modifiers of the glycerol kinase deficiency phenotype. PMID: 16549535

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Involvement in disease
Glycerol kinase deficiency (GKD)
Subcellular Location
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
Protein Families
FGGY kinase family
Tissue Specificity
Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.
Database Links

HGNC: 4289

OMIM: 300474

KEGG: hsa:2710

UniGene: Hs.1466

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