GK Antibody

Datasheet

Code	CSB-PA902246
Size	US$297
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Image	Western blot analysis of extracts from 293 cells and Jurkat cells, using GLPK antibody. Immunofluorescence analysis of HeLa cells, using GLPK antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GK Polyclonal antibody

Uniprot No.

P32189

Target Names

Alternative Names

ATP glycerol 3 phosphotransferase antibody; ATP:glycerol 3 phosphotransferase antibody; ATP:glycerol 3-phosphotransferase antibody; D930012N15Rik antibody; GK antibody; GK1 antibody; GKD antibody; GLPK_HUMAN antibody; Glycerokinase antibody; Glycerol kinase antibody; OTTHUMP00000023108 antibody; OTTHUMP00000023109 antibody; OTTHUMP00000215321 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from C-terminal of Human GLPK.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IF	1:100-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Key enzyme in the regulation of glycerol uptake and metabolism.

Gene References into Functions

Both patients were found to have Xp21.2 deletions involving all coding seqeunces of the glycerol kinase (GK) gene. PMID: 27087023
Two siblings with the contiguous X-linked gene deletion syndrome, complex glycerol kinase deficiency, are described. The elder sibling demonstrates the difficulties diagnosing this rare condition. PMID: 20110216
missense mutations and deletions in glycerol kinase is associated with persistent hypertriglyceridemia PMID: 12636049
a functional HNF-4alpha binding site in the first 500 bp of the 5(') upstream region is important for increased levels of glycerol kinase expression PMID: 14654354
Comparison of expression patterns, as well as enzymatic characteristics and subcellular localization of alternatively spliced glycerol kinase isoforms. PMID: 15845384
Results suggest that influences on RNA processing and protein stability represent modifiers of the glycerol kinase deficiency phenotype. PMID: 16549535

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Involvement in disease

Glycerol kinase deficiency (GKD)

Subcellular Location

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.

Protein Families

FGGY kinase family

Tissue Specificity

Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.

Database Links

HGNC: 4289

OMIM: 300474

KEGG: hsa:2710

UniGene: Hs.1466

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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