ADGRG6 Antibody

Code CSB-PA768200ESR1HU
Size US$166
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  • Western blot
    All lanes: CD1C antibody at 4.61μg/ml
    Lane 1: Mouse brain tissue
    Lane 2: Mouse lung tissue
    Lane 3: 293T whole cell lysate
    Lane 4: HepG2 whole cell lysate
    Lane 5: Jurkat whole cell lysate
    Lane 6: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 137, 134, 140 kDa
    Observed band size: 137 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA768200ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ADGRG6 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
adhesion G protein coupled receptor G6 antibody; APG1 antibody; Developmentally regulated G protein coupled receptor antibody; Developmentally regulated G-protein-coupled receptor antibody; dj287g14.2 antibody; DREG antibody; G protein coupled receptor 126 antibody; G-protein coupled receptor 126 antibody; GP126_HUMAN antibody; GPR126 antibody; HBV PreS1 transactivated protein 2 antibody; HBV PreS1-transactivated protein 2 antibody; LCCS9 antibody; OTTHUMP00000017320 antibody; OTTHUMP00000237093 antibody; OTTHUMP00000237094 antibody; OTTHUMP00000237115 antibody; PR126 antibody; Probable G protein coupled receptor 126 [Precursor] antibody; Probable G protein coupled receptor 126 antibody; Probable G-protein coupled receptor 126 [Precursor] antibody; Probable G-protein coupled receptor 126 antibody; PS1TP2 antibody; Vascular inducible G protein coupled receptor antibody; Vascular inducible G protein-coupled receptor antibody; VIGR antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Adhesion G-protein coupled receptor G6 protein (40-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.
Gene References into Functions
  1. The association of a single nucleotide polymorphism in GPR126 with aggressive periodontitis in a Japanese population. The role of GPR126 in maintaining the homeostasis of periodontal ligament tissues. PMID: 27509131
  2. Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS) and pectus excavatum in a mouse model. PMID: 25954032
  3. Genetic variants of GPR126 gene are associated with adolescent idiopathic scoliosis susceptibility in Chinese populations. PMID: 25479386
  4. Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. PMID: 26004201
  5. GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling PMID: 25217645
  6. Gpr126 functions in Schwann cells for proper development and myelination through G-protein-signaling pathways. PMID: 24227709
  7. A single nucleotide polymorphism in the GPR126 gene is associated with increased susceptibility for adolescent idiopathic scoliosis. [Meta-analysis] PMID: 23666238
  8. Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. PMID: 21929287
  9. The PS1TP2 gene was located at 6q24.1, and interacts with leukocyte proteins. PMID: 18304421
  10. VIGR represents a novel G protein coupled receptors of the adhesion family, which is unique in its long extra-cellular domain. PMID: 15225624
  11. APG1 formed an alpha-helical structure at the C-terminal site and a positive charge cluster at the N-terminal site. PMID: 17109822

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Involvement in disease
Lethal congenital contracture syndrome 9 (LCCS9)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Tissue Specificity
Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
Database Links

HGNC: 13841

OMIM: 606255

KEGG: hsa:57211

STRING: 9606.ENSP00000356581

UniGene: Hs.743302

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