GRM1 Antibody

Datasheet
Code CSB-PA009931GA01HU
Size US$685
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Product Details

Uniprot No. Q13255
Target Names GRM1
Alternative Names Glutamate receptor metabotropic 1 antibody; glutamate receptor; metabotropic 1 antibody; GPRC1A antibody; GRM1 antibody; GRM1-Alpha antibody; GRM1_HUMAN antibody; GRM1A antibody; Metabotropic glutamate receptor 1 antibody; mGlu1 antibody; mGluR1 antibody; MGLUR1-Alpha antibody; MGLUR1A antibody; SCAR13 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human GRM1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Gene References into Functions
  1. Age-dependent increase in metabotropic glutamate receptor type 1 availability in several brain regions may exist predominantly in males. PMID: 28431287
  2. Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44. PMID: 28886343
  3. our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias. PMID: 26748626
  4. a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability. PMID: 26308914
  5. It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor and mutually modulate signaling. PMID: 26154847
  6. These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability. PMID: 26291396
  7. Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target. PMID: 25859923
  8. elevated glutamate secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation PMID: 25299066
  9. alpha-actinin-4 is a novel group 1 mGluR-interacting partner that orchestrates spine dynamics and morphogenesis in neurons. PMID: 25944910
  10. These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling. PMID: 25062106
  11. Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor as well as a mediator of tumor progression. PMID: 24633367
  12. In mice expressing mutant beta-III spectrin, mGluR1 localization is altered at Purkinje cell dendritic spines. PMID: 25057192
  13. mGluR1 cooperates with other factors in hyperplastic mammary epithelium to contribute to TNBC progression PMID: 24404125
  14. reflected in the immunoblotting data Mglur1 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. PMID: 25003238
  15. GRM1 activation triggers proangiogenic signaling in melanoma. PMID: 24491800
  16. GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. PMID: 24658000
  17. mGluR1-dependent synaptic transmission in the cerebellum is regulated by STIM1 in neuronal Ca(2) signaling. PMID: 24811382
  18. These findings suggest a functional role for GRM1 in breast cancer. PMID: 23922822
  19. structure determined of the mGlu1 receptor seven-transmembrane (7TM) domain bound to a negative allosteric modulator, FITM, at a resolution of 2.8 angstroms PMID: 24603153
  20. During ischemia, mGluR1 activation improves cortical astrocytes and GABAergic neurons. PMID: 23109136
  21. Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1alpha PMID: 24280223
  22. It regulates synaptic response, exitability of neurons and secretion of neurotransmitters. (review) PMID: 24334926
  23. mGluR1 recruitment to lipid rafts is enhanced by agonist binding and is supported at least in part by an intact cholesterol recognition/interaction amino acid consensus (CRAC) motif in the receptor. PMID: 24045944
  24. Grm1 indeed can be oncogenic in epithelial cells and can activate the multiple characteristic cancer-signaling pathways-and that components of the glutamatergic system are active in RCC. PMID: 23085756
  25. Suppression of GRM1 expression in several human melanoma cell lines resulted in a reduction in the number of viable cells and a decrease in stimulated mitogen-activated protein kinase (MAPK) and PI3K/AKT and suppressed tumor progression in vivo. PMID: 22798429
  26. This new splice variant, mGlu1h receptor, is encoded by two previously unidentified exons located within the human GRM1 gene, and these new exons are found exclusively within the GRM1 genes of higher primates and are highly conserved. PMID: 23481697
  27. Somatic mutations in mGluR1a disrupt signaling in cancer with multiple downstream consequences. PMID: 23303475
  28. demethylation within the promoter region of GRM1 may also be a mechanism for the derepression of mGluR1 expression in melanocytes that progress to cell transformation and tumor formation. PMID: 22771868
  29. These experiments provide us with an understanding of the role Rabs play in coordinated regulation of mGluR1a and how this impacts mGluR1a signaling PMID: 23175844
  30. Only a single subunit assumes an active state in an mGluR1 receptor dimer. PMID: 22894836
  31. The study implicates mGluR1 in human hereditary ataxia. PMID: 22901947
  32. Normal, non-mutated CFTR, as well as mutated forms of CFTR were associated with metabotropic mGluR1. PMID: 22520513
  33. Deleterious GRM1 mutations are associated with schizophrenia. PMID: 22448230
  34. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248. PMID: 22460132
  35. Within the GRM1 locus, 22 SNPs showed nominally significant association with UPD, of which 6 withstood corrections for multiple testing. PMID: 21962378
  36. Observations implicate mGluR1 and glutamate signaling as a promising new molecular target for the treatment of breast cancer. PMID: 21681448
  37. These data indicate group I mGluRs are highly expressed on oligodendrocytes during the peak period of vulnerability to HI and modulation of mGluRs is protective in a rodent model of periventricular leukomalacia. PMID: 22169210
  38. Disruption of mGluR1 signaling at parallel fiber-Purkinje cell synapses is a major synaptic defect in homozygous staggerer mice, correlating with spinocerebellar ataxia (SCA) type 1 pathology in the extreme mouse model. PMID: 21558162
  39. analysis of clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder PMID: 21559497
  40. Studies indicate that FXS has been linked to altered group I metabotropic glutamate receptor (mGluR)-dependent, and potential targeted therapeutic strategies developed to specifically correct disturbances in the excitatory mGluR. PMID: 20864408
  41. Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation. PMID: 20705606
  42. These findings show a differential expression pattern of mGluR1a and mGluR5, suggesting a role for both receptors in the early stages of corticogenesis with, however, a different contribution to human cortical developmental events. PMID: 20149785
  43. Absence of mutations in a relatively small cohort of patients appears to suggest that mutations in GRM1 are not frequent in cerebellar ataxias. PMID: 19924463
  44. Taken together, these results showed that, in addition to the MAPK pathway previously reported being a downstream target of stimulated Grm1, AKT2 is another downstream target in Grm1 mediated melanocyte transformation. PMID: 19843246
  45. In patients with mesial temporal lobe epilepsy, mGluR1 may increase hippocampal excitability through postsynaptic activation. PMID: 11951051
  46. internalization of mGluR1 splice variants is subject to PKC and CaMKII regulation. PMID: 11961129
  47. identification of crucial residues for setting the activated state PMID: 12444084
  48. Melanoma model implicates metabotropic glutamate signaling in melanocytic neoplasia. PMID: 12704387
  49. PKA activation inhibits the agonist-induced internalization and desensitization of mGluR1a and mGluR1b, probably by reducing their interaction with GRK2 and nonvisual arrestins. PMID: 15155843
  50. metabotropic glutamate receptors 1 and 5 mediate opposite glutamate effects in human lymphocyte activation PMID: 15184389
  51. Stimulation of glial mGluR1 through mediators present in the cerebrospinal fluid may contribute to glial proliferation and astrogliosis in amyotrophic lateral sclerosis. PMID: 15330338
  52. These results show that mGlu1alpha receptor interacts with caveolins and that this interaction is physiologically relevant for receptor function. PMID: 15383311
  53. mutant/wild-type heterodimeric group I metabotropic glutamate receptors are inactive at ligand concentrations favoring glutamate association with receptor dimers at only one subunit PMID: 15466247
  54. examined whether both heptahelical domains are turned on upon full receptor activation PMID: 15660124
  55. kinase binding to an mGluR1 domain involved in G protein-coupling is essential for the phosphorylation-independent attenuation of signaling by GRK2 PMID: 15870073
  56. This study found an increase in the expression of mGluR1a and mGluR2/3 immunoreactivity in the PFC in schizophrenia. PMID: 15945063
  57. group I mGluRs/PLC signaling are down-regulated and desensitized in the frontal cortex in cDLB and AD cases and that these modifications worsen with progression of AD changes in the cerebral neocortex. PMID: 15949941
  58. mGLuR1a signaling is attenuated by the huntingtin-binding protein optineurin PMID: 16091361
  59. Human melanoma cells release elevated levels of glutamate, implying a possible autocrine loop via GRM1. PMID: 17332361
  60. Results describe the structure of the Metabotropic glutamate receptor 1 (mGlu1)gene and demonstrated that mGlu1 transcription takes places at alternative first exons. PMID: 17430891
  61. May contribute to melanoma susceptibility in a subgroup of patients with a low level of sun exposure and tumors located on the trunk and extremities. PMID: 17609672
  62. Expression of mGluR1 increases in human with hypothalamic hamartoma and in the female monkey hypothalamus at puberty. PMID: 18059092
  63. The proline-993-serine amino acid substitution is a highly frequent polymorphism in the human mGluR1 gene. PMID: 19146831
  64. Present study points to ImGluR(V), a depolarization-activated inward current, as the cellular mechanism for group I mGluR-mediated epileptogenesis. PMID: 19295155
  65. Amplification and sequencing of cDNA and genomic DNA allowed the identification of 10 nonsynonymous single nucleotide polymorphisms (nsSNPs) in tas1r1 (n = 3), tas1r3 (n = 3), and mGluR1 (n = 4). PMID: 19571223
  66. the association of CAIN with intracellular domains involved in mGluR/G protein coupling provides a mechanism by which Group I mGluR endocytosis and signaling are regulated PMID: 19717561

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Involvement in disease Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13); Spinocerebellar ataxia 44 (SCA44)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 3 family
Tissue Specificity Detected in brain.
Database Links

HGNC: 4593

OMIM: 604473

KEGG: hsa:2911

STRING: 9606.ENSP00000282753

UniGene: Hs.32945

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