GRM4 Antibody

Code CSB-PA003235
Size US$100
Order now
Image
  • Western Blot analysis of 293 cells using mGluR-4 Polyclonal Antibody
  • Western Blot analysis of RAT-KIDNEY cells using mGluR-4 Polyclonal Antibody
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
GRM4
Alternative Names
Glutamate receptor metabotropic 4 antibody; GPRC1D antibody; Grm4 antibody; GRM4_HUMAN antibody; Metabotropic glutamate receptor 4 antibody; mGlu4 antibody; mGluR4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human mGluR-4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Gene References into Functions
  1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID: 29339716
  2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID: 27792966
  3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID: 26276359
  4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID: 24984297
  5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID: 24840839
  6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID: 24925192
  7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID: 25342125
  8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
  9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID: 20338729
  10. residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID: 15184361
  11. mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID: 15217955
  12. Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID: 15867225
  13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID: 16582932
  14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
  15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID: 17884634

Show More

Hide All

Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
Database Links

HGNC: 4596

OMIM: 604100

KEGG: hsa:2914

STRING: 9606.ENSP00000363296

UniGene: Hs.429018

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*