GTF2E2 Antibody

Code CSB-PA010003LA01HU
Size US$166
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  • Western blot
    All lanes: GTF2E2 antibody at 2µg/ml
    Lane 1: Mouse brain tissue
    Lane 2: Hela whole cell lysate
    Lane 3: MCF-7 whole cell lysate
    Lane 4: PC-3 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 34 kDa
    Observed band size: 34 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GTF2E2 Polyclonal antibody
Uniprot No.
Target Names
GTF2E2
Alternative Names
FE antibody; General transcription factor IIE subunit 2 antibody; General transcription factor IIE; polypeptide 2; beta 34kDa antibody; gtf2e2 antibody; T2EB_HUMAN antibody; TF2E 2 antibody; TF2E2 antibody; TFIIE B antibody; TFIIE-beta antibody; Transcription initiation factor IIE beta subunit antibody; Transcription initiation factor IIE subunit beta antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Transcription initiation factor IIE subunit beta protein (1-291AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GTF2E2 Antibody (Product code: CSB-PA010003LA01HU) is Non-conjugated. For GTF2E2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA010003LB01HU GTF2E2 Antibody, HRP conjugated ELISA
FITC CSB-PA010003LC01HU GTF2E2 Antibody, FITC conjugated
Biotin CSB-PA010003LD01HU GTF2E2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Gene References into Functions
  1. functional analysis of Trichothiodystrophy causative TFIIEbeta mutation demonstrates that mutant TFIIEbeta strongly reduces the total amount of the entire TFIIE complex, with a remarkable temperature-sensitive transcription defect. PMID: 28973399
  2. We underline role of TFIIE in transcription and its distinction from nucleotide excision repair. Trichothiodystrophy individuals with mutations in GTF2E2 highlight the importance of the direct interaction between TFIIH and TFIIE in transcription process. PMID: 26996949
  3. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
  4. introduced point mutations into two regions located near the carboxy terminus of TFIIE beta and identified the functionally essential amino acid residues that bind to RNA polymerase II PMID: 12665589
  5. TFIIE is an alpha/beta heterodimer in solution; A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation. PMID: 16547462
  6. These data suggest a model in which TFIIE binds to a position adjacent to the initiation site via the forkhead domain, enabling TFIIH to begin opening the promoter. PMID: 19210545

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Involvement in disease
Trichothiodystrophy 6, non-photosensitive (TTD6)
Subcellular Location
Nucleus.
Protein Families
TFIIE beta subunit family
Database Links

HGNC: 4651

OMIM: 189964

KEGG: hsa:2961

STRING: 9606.ENSP00000348168

UniGene: Hs.77100

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