GZMK Antibody

1. Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1. PMID: 26936634
2. Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response. PMID: 24711407
3. Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells. PMID: 21666061
4. Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3. PMID: 20377743
5. The 2.2-A crystal structure reveals a rigid zymogen with unusual features PMID: 12384499
6. The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart. PMID: 12387726
7. We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks. PMID: 17008916
8. Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis. PMID: 17438453
9. p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy. PMID: 19201868

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HGNC: 4711

OMIM: 600784

KEGG: hsa:3003

STRING: 9606.ENSP00000231009

UniGene: Hs.277937