GZMK

GZMK, also known as granzyme M, is a member of the serine protease family encoded by the GZMK gene. It is expressed within cytotoxic T lymphocytes and natural killer (NK) cells, where it plays a role in immune responses by inducing apoptosis in target cells through the synergistic action with other enzymes found in cytotoxic granules. Dysregulation of GZMK, including changes in its expression and activity, has been linked to various conditions, notably autoimmune diseases and cancer, highlighting its potential as a target for immunological research and therapeutic interventions.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GZMK Antibody (CSB-PA010084LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA010084LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA010084LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA010084LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following GZMK reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GZMK Antibodies

GZMK Proteins

GZMK Antibodies

GZMK Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002797	GZMK Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA886920	GZMK Antibody	Human	ELISA,IHC
CSB-PA057029	GZMK Antibody	Human	ELISA,IHC
CSB-PA010084LA01HU	GZMK Antibody	Human	ELISA, IHC, IF
CSB-PA010084LB01HU	GZMK Antibody, HRP conjugated	Human	ELISA
CSB-PA010084LC01HU	GZMK Antibody, FITC conjugated	Human
CSB-PA010084LD01HU	GZMK Antibody, Biotin conjugated	Human	ELISA

GZMK Proteins

GZMK Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP010084HU CSB-BP010084HU CSB-MP010084HU CSB-EP010084HU-B	Recombinant Human Granzyme K (GZMK)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP010084HU	Recombinant Human Granzyme K (GZMK)	E.coli
CSB-EP010084HUc7	Recombinant Human Granzyme K (GZMK)	E.coli
CSB-EP010084HU1	Recombinant Human Granzyme K (GZMK)	E.coli
CSB-EP010084HU1g5	Recombinant Human Granzyme K (GZMK)	E.coli
CSB-EP010084HU1d7	Recombinant Human Granzyme K (GZMK)	E.coli

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Popular Pathways

Apoptosis

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Hippo signaling pathway

TGF-beta signaling pathway

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GZMK

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