Gnao1 Antibody

1. Galphao +/- mice developed tolerance faster and displayed more severe naltrexone-precipitated withdrawal in some behaviors than did wild-type PMID: 28971229
2. Go signaling is essential for the structural and functional integrity of the main olfactory epithelium and for specification of olfactory bulb interneurons. PMID: 27625425
3. Data obtained support the hypothesis that GalphaO-mediated signaling within the presympathetic circuits of the rostral ventral lateral medulla contributes to the autonomic control of the heart. PMID: 27528004
4. Necdin is a candidate downstream effector for Galphao. PMID: 25012566
5. This heterozygous Gnao1 +/G184S mutation produces early neonatal and adult lethality accompanied by epileptiform discharges. PMID: 24700286
6. These results highlight that sensory neurons of the Galphao-expressing vomeronasal subsystem, together with the receptors they express and the molecular cues they detect, control a wide range of fundamental mating and reproductive behaviors in female mice. PMID: 24886577
7. The Goalpha expressing vomeronasal receptor cells led to all areas of the accessory olfactory bulb (AOB). PMID: 22383629
8. Data indicate that rectifying potassium channel Kir2.4 interacts with G-protein subunit Galphao. PMID: 23339194
9. Data show that Galphao is an essential requirement for the display of male-male territorial aggression as well as maternal aggression. PMID: 21768373
10. Data suggest that the novel R234H mutation imparts oncogenic properties to Galphao by accelerating nucleotide exchange and rendering it constitutively active. PMID: 21317923
11. The 2.9 A crystal structure of the enigmatic, neuronal G protein Galpha(o) in the GTP hydrolytic transition state, complexed with RGS16. PMID: 18434540
12. Go alpha subunit mainly appears to be bound to the cell membrane and concentrated in the thin finger-like dendrites of rod bipolar cells, as well as in green fluorescent protein-positive cone bipolar cells. PMID: 12454992
13. Binding of activated Galphao to GRIN1 induces activation of Cdc42, which leads to morphological changes in neuronal cells. PMID: 15585744
14. our findings establish an essential role for G(o) in the antiadrenergic effect of muscarinic agent on hyperpolarization current PMID: 18156202
15. Go2alpha optimizes vesicular filling which is instrumental for normal dopamine functioning and for the development of drug-induced behavioral sensitization. PMID: 18606864
16. Data show that Galphao colocalized with GRIN1 at neuronal dendrites and axons, and Galphao-GRIN1 pathway could mediate roles in neuronal migration and differentiation at embryonic stages. PMID: 18729205
17. Report role of Galpha0 in the control of in vivo heart rate dynamics. PMID: 18832081
18. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. PMID: 19225179
19. The G alpha(o) protein in the locus coeruleus as contributing to interindividual variability in physical dependence on opioids in mice. PMID: 19460419
20. Data indicate that MC4R mutant is able to selectively interact with G(i/o) proteins. PMID: 19648111

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KEGG: mmu:14681

STRING: 10090.ENSMUSP00000034198

UniGene: Mm.251445