Gstp1 Antibody

Code CSB-PA009989HA01MO
Size US$166
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  • Western blot
    All lanes: Gstp1 antibody at 2µg/ml
    Lane 1: Mouse kidney tissue
    Lane 2: Jurkat whole cell lysate
    Lane 3: K562 whole cell lysate
    Lane 4: 293T whole cell lysate
    Lane 5: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 24 kDa
    Observed band size: 24 kDa
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Gstp1 Polyclonal antibody
Uniprot No.
Target Names
Gstp1
Alternative Names
Gstp1 antibody; GstpibGlutathione S-transferase P 1 antibody; Gst P1 antibody; EC 2.5.1.18 antibody; GST YF-YF antibody; GST class-pi antibody; GST-piB antibody; Preadipocyte growth factor antibody
Raised in
Rabbit
Species Reactivity
Mouse, Human
Immunogen
Recombinant Mouse Glutathione S-transferase P 1 protein (2-210AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Gstp1 Antibody (Product code: CSB-PA009989HA01MO) is Non-conjugated. For Gstp1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009989HB01MO Gstp1 Antibody, HRP conjugated ELISA
FITC CSB-PA009989HC01MO Gstp1 Antibody, FITC conjugated
Biotin CSB-PA009989HD01MO Gstp1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Gene References into Functions
  1. Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members. PMID: 27058114
  2. GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid. PMID: 26838680
  3. our study reveals the novel role of GSTP1 in regulation of iNOS by affecting S-nitrosylation, dimerization, and stability. PMID: 26361746
  4. These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected] PMID: 25216273
  5. GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation. PMID: 24664677
  6. GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress. PMID: 23129554
  7. Report increased GSTP1 in airways of asthmatic mice. PMID: 23647087
  8. DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity PMID: 22084240
  9. Gst-pi expression of the prostate cancers are dependent on metastatic site. PMID: 21748757
  10. GSTP plays a major role in carcinogenesis distinct from its role in detoxification and provides evidence that the enzyme is a key determinant of the proinflammatory tumor environment. PMID: 21975931
  11. This study analysed the kinetic behaviour of all the various cysteine to alanine mutants of Gstp1. These mutations introduce cooperativity and a novel 'ping pong' mechanism in the case of the C169A mutant. PMID: 21134126
  12. Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines PMID: 20538586
  13. role in activating Pi-class glutathione S-transferase gene in conjunction with androgens PMID: 12023900
  14. Differential expression of GSTpi contributes to the sensitivity to xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders including Parkinson's disease. PMID: 17267597
  15. GSTP1 attenuates the severity of allergic airways disease. However, the efficacy of GSTP1 correlated with mouse strain-dependent variation in Gstp1 expression. PMID: 18787219
  16. Results suggest that GSTpi expression may be part of the mechanism underlying the ability of glial cells to elicit protection against the mechanisms involved in MPTP-induced neuronal death. PMID: 18792812
  17. GSTP1 prevented LPS-induced TNF-alpha, IL-1beta, MCP-1 and NO production. PMID: 18962899
  18. Catalysis of S-glutathionylation at low pK cysteines in proteins is a novel property for GSTpi PMID: 18990698

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Subcellular Location
Cytoplasm. Mitochondrion. Nucleus.
Protein Families
GST superfamily, Pi family
Tissue Specificity
Ubiquitously expressed.
Database Links
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