HNRNPM Antibody

Code CSB-PA010613ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010613ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010613ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HNRNPM Polyclonal antibody
Uniprot No.
Target Names
HNRNPM
Alternative Names
CEA receptor antibody; CEAR antibody; Heterogeneous nuclear ribonucleoprotein M antibody; Heterogenous nuclear ribonucleoprotein M4 antibody; hnRNA binding protein M4 antibody; hnRNP M antibody; Hnrnpm antibody; HNRNPM4 antibody; HNRPM antibody; HNRPM_HUMAN antibody; HNRPM4 antibody; HTGR1 antibody; M3 antibody; M4 antibody; M4 protein antibody; N-acetylglucosamine receptor 1 antibody; NAGR1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Heterogeneous nuclear ribonucleoprotein M protein (491-730AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Gene References into Functions
  1. Overexpression of hnRNPM promotes breast cancer aggressiveness by regulating the level of CD44s and indicates a poor prognosis. PMID: 28393427
  2. Data suggest that both heterogeneous nuclear ribonucleoprotein type M (HNRPM) and solute carrier 1A5 (SLC1A5) have role in the pathogenesis of ovarian cancer. PMID: 28609484
  3. p54nrb and hnRNPM knockdown silences the FGF1 promoter-dependent accumulation of mRNA during myoblast differentiation. PMID: 26332123
  4. Results suggest that glyceraldehyde-modified hnRNPM alters gene expression in nonalcoholic fatty liver disease. PMID: 25684943
  5. The authors propose that cleavage of and subverting the function of hnRNPM by 3C protease is a general strategy utilized by picornaviruses to facilitate viral infection. PMID: 25926642
  6. our data suggest that TAF15 and TLS/FUS operate within similar but not identical hnRNP M-TET protein complexes to influence the transcriptional or post-transcriptional output of a particular cell type. PMID: 24474660
  7. findings demonstrate a novel molecular mechanism through which tumor metastasis is endowed by the hnRNPM-mediated splicing program. PMID: 24840202
  8. Our results provide a clue that hnRNP M is a potential therapeutic target for Spinal muscular atrophy PMID: 24533984
  9. The present data demonstrate that the upregulation of HnRNP M is involved in human colorectal epithelial carcinogenesis and may serve as a carcinoma biomarker for colorectal cancer. PMID: 24381081
  10. Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M. PMID: 21398516
  11. A central region in hnRNP-M is required for interaction with CDC5L/PLRG1. PMID: 20467437
  12. PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54(nrb), two highly related proteins involved in transcription and RNA processing, are identified as new binding partners of hnRNP M. PMID: 19874820
  13. mitochondrial ribosomal protein S12 3'-UTR interacts specifically with TRAP1 (tumor necrosis factor receptor-associated protein1), hnRNPM4 (heterogeneous nuclear ribonucleoprotein M4), Hsp70 and Hsp60 (heat shock proteins 70 and 60), and alpha-tubulin PMID: 18790094

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Subcellular Location
Nucleus, nucleolus.
Database Links

HGNC: 5046

OMIM: 160994

KEGG: hsa:4670

STRING: 9606.ENSP00000325376

UniGene: Hs.465808

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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