HOXB1 Antibody

Datasheet

Code	CSB-PA064404
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA064404(HOXB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA064404(HOXB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P14653

Target Names

HOXB1

Alternative Names

HCFP3 antibody; Homeo box 2I antibody; Homeo box B1 antibody; Homeobox 2I antibody; Homeobox B1 antibody; Homeobox protein Hox B1 antibody; Homeobox protein Hox-2I antibody; Homeobox protein Hox-B1 antibody; Homeobox protein HoxB1 antibody; Homeobox2I antibody; HomeoboxB1 antibody; HOX 2 antibody; Hox 2.9 antibody; HOX 2I antibody; HOX B1 antibody; HOX2 antibody; Hox2.9 antibody; HOX2I antibody; HOXB 1 antibody; HOXB1 antibody; HOXB1 protein antibody; HXB1_HUMAN antibody; MGC116843 antibody; MGC116844 antibody; MGC116845 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human HOXB1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:40-1:150

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Gene References into Functions

This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator PMID: 27144914
findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3) PMID: 27640920
HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma. PMID: 26565624
The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype. PMID: 22770981
Hoxb1 Expression Induces Cell Fate Changes in the Trunk Neural Tube. PMID: 21433221
analysis of a tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations PMID: 20371328
Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes. PMID: 19477923
It is unlikely that HoxB1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
UTX directly binds to the HOXB1 locus and is required for its activation PMID: 17713478
HoxB1 interacts with Pax6 and enhances its transcriptional activity. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human HoxB1. PMID: 11069920

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Involvement in disease

Facial paresis, hereditary congenital, 3 (HCFP3)

Subcellular Location

Nucleus.

Protein Families

Antp homeobox family, Labial subfamily

Database Links

HGNC: 5111

OMIM: 142968

KEGG: hsa:3211

STRING: 9606.ENSP00000355140

UniGene: Hs.99992

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Signaling pathways regulating pluripotency of stem cells Cell markers

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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