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HOXB1/HOXA1/HOXD1 Antibody

Datasheet
Code CSB-PA028363
Size US$297
Image
  • Immunohistochemistry analysis of paraffin-embedded human testis tissue, using HOXA1/B1/D1 antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) HOXB1/HOXA1/HOXD1 Polyclonal antibody
Uniprot No. P14653
Target Names HOXB1/HOXA1/HOXD1
Alternative Names HCFP3 antibody; Homeo box 2I antibody; Homeo box B1 antibody; Homeobox 2I antibody; Homeobox B1 antibody; Homeobox protein Hox B1 antibody; Homeobox protein Hox-2I antibody; Homeobox protein Hox-B1 antibody; Homeobox protein HoxB1 antibody; Homeobox2I antibody; HomeoboxB1 antibody; HOX 2 antibody; Hox 2.9 antibody; HOX 2I antibody; HOX B1 antibody; HOX2 antibody; Hox2.9 antibody; HOX2I antibody; HOXB 1 antibody; HOXB1 antibody; HOXB1 protein antibody; HXB1_HUMAN antibody; MGC116843 antibody; MGC116844 antibody; MGC116845 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from internal of Human HOXA1/B1/D1.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Gene References into Functions
  1. This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator PMID: 27144914
  2. findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3) PMID: 27640920
  3. HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma. PMID: 26565624
  4. The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype. PMID: 22770981
  5. Hoxb1 Expression Induces Cell Fate Changes in the Trunk Neural Tube. PMID: 21433221
  6. analysis of a tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations PMID: 20371328
  7. Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes. PMID: 19477923
  8. It is unlikely that HoxB1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
  9. UTX directly binds to the HOXB1 locus and is required for its activation PMID: 17713478
  10. HoxB1 interacts with Pax6 and enhances its transcriptional activity. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human HoxB1. PMID: 11069920

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Involvement in disease Facial paresis, hereditary congenital, 3 (HCFP3)
Subcellular Location Nucleus
Protein Families Antp homeobox family, Labial subfamily
Database Links

HGNC: 5111

OMIM: 142968

KEGG: hsa:3211

STRING: 9606.ENSP00000355140

UniGene: Hs.99992
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