HSBP1 Antibody

Datasheet

Code	CSB-PA00454A0Rb
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA00454A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA00454A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) HSBP1 Polyclonal antibody

Uniprot No.

O75506

Target Names

HSBP1

Alternative Names

Heat shock factor binding protein 1 antibody; Heat shock factor-binding protein 1 antibody; HSBP1 antibody; HSBP1_HUMAN antibody; HSF1BP antibody; Nasopharyngeal carcinoma associated antigen 13 antibody; Nasopharyngeal carcinoma-associated antigen 13 antibody; NPC A 13 antibody; NPC-A-13 antibody; NPCA 13 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Heat shock factor-binding protein 1 protein (1-75AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The HSBP1 Antibody (Product code: CSB-PA00454A0Rb) is Non-conjugated. For HSBP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA00454B0Rb	HSBP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA00454C0Rb	HSBP1 Antibody, FITC conjugated
Biotin	CSB-PA00454D0Rb	HSBP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Gene References into Functions

HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis. PMID: 28828227
Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity. PMID: 28332148
HSBP1 is crucial for regulating resistance to radiotherapy of oral squamous epithelial carcinoma cells by inducing stem-like status. PMID: 24816843
HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1 PMID: 21247889
This study reports the crystal structure of a degradation-resistant fragment of HSBP1. A continuous, long-helix conformation of HSBP1 assembles into a coiled-coil three-helix bundle and subsequently into an elongated, symmetrical hexamer. PMID: 18767159
HSBP likely mediates its function through its trimerization domain. PMID: 11679589

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Subcellular Location

Nucleus.

Protein Families

HSBP1 family

Database Links

HGNC: 5203

OMIM: 604553

KEGG: hsa:3281

STRING: 9606.ENSP00000392896

UniGene: Hs.250899

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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