HSD17B11 Antibody

Datasheet

Code	CSB-PA000765
Size	US$100
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Image	Western Blot analysis of 293 cells using 17β-HSD11 Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NBQ5

Target Names

HSD17B11

Alternative Names

17 beta HSD 11 antibody; 17 beta HSD XI antibody; 17 BETA HSD11 antibody; 17 BETA HSDXI antibody; 17 beta hydroxysteroid dehydrogenase 11 antibody; 17 beta hydroxysteroid dehydrogenase type XI antibody; 17 beta hydroxysteroid dehydrogenase XI antibody; 17-beta-HSD 11 antibody; 17-beta-HSD XI antibody; 17-beta-hydroxysteroid dehydrogenase 11 antibody; 17-beta-hydroxysteroid dehydrogenase XI antibody; 17betaHSD11 antibody; 17betaHSDXI antibody; 17bHSD11 antibody; CTCL associated antigen HD CL 03 antibody; CTCL tumor antigen HD CL 03 antibody; CTCL-associated antigen HD-CL-03 antibody; Cutaneous T cell lymphoma associated antigen HD CL 03 antibody; Cutaneous T-cell lymphoma-associated antigen HD-CL-03 antibody; Dehydrogenase/reductase SDR family member 8 antibody; DHB11_HUMAN antibody; DHRS8 antibody; Estradiol 17 beta dehydrogenase 11 antibody; Estradiol 17-beta-dehydrogenase 11 antibody; Hsd17b11 antibody; Hydroxysteroid (17 beta) dehydrogenase 11 antibody; PAN1B antibody; Retinal short chain dehydrogenase/reductase 2 antibody; Retinal short-chain dehydrogenase/reductase 2 antibody; RETSDR2 antibody; SDR16C2 antibody; SDR2 antibody; Short chain dehydrogenase/reductase family 16C member 2 antibody; T cell lymphoma associated antigen HD CL 03 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human 17β-HSD11.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Gene References into Functions

knowledge of its in vitro activity together with a newly described expression pattern at the protein level in tissues involved in steroidogenesis and detoxification could suggest a potential role of DHRS8 in vivo PMID: 26472732
hydroxysteroid (17-beta) dehydrogenase 11 transcription in prostate cancer cells is regulated by Sp1 transcription factor and C-EBP alpha PMID: 21549806
Role for 17-beta-HSDXI in androgen metabolism during steroidogenesis. PMID: 12697717
Mutation analyses suggest that the PAT-like motif in 17betaHSD11 will not be functionally similar to the canonical PAT motif. PMID: 18804447
Increased Pan1b is associated with prostate cancer of seminal vesicle invasion. PMID: 19469652

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Subcellular Location

Endoplasmic reticulum. Lipid droplet.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily

Tissue Specificity

Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in

Database Links

HGNC: 22960

OMIM: 612831

KEGG: hsa:51170

STRING: 9606.ENSP00000351035

UniGene: Hs.594923

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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