HSPH1 Antibody

1. expression not an independent prognostic factor in gastric cancer patients with peritoneal metastasis, but might be a new marker of chemosensitivity PMID: 29204054
2. Established heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability-high (MSI-H) by considering the intratumoral heterogeneity of HSP110 expression. The HSP110wt-low MSI-H CRCs were significantly correlated with larger deletions in the HSP110 T17 mononucleotide repeat (>/=4 bp; p < 0.001). PMID: 28971530
3. HSP110 HT17 alone correctly classified samples judged to be uncertain with the pentaplex panel. PMID: 26831756
4. deletion of the HSP110 T17 repeat was frequently observed in microsatellite-unstable advanced gastric cancers. PMID: 28811251
5. Hsp105alpha localizes to the nucleus, interacts with HIF-1alpha and induces HIF-1a accumulation in CoCl2-treated cells. PMID: 28185835
6. the expression of HSP110 in colon cancer contributes to STAT3-dependent tumor growth PMID: 27819670
7. About 25% of patients with stages II-III colorectal tumors with microsatellite instability have an excellent response to chemotherapy, due to large, biallelic deletions in the T(17) intron repeat of HSP110 in tumor DNA. PMID: 24512910
8. HSP105 depletion disrupts the integration of protein phosphatase 2A into the beta-catenin degradation complex, favoring the hyperphosphorylation and degradation of beta-catenin. PMID: 25645927
9. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. PMID: 24157810
10. we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105. These studies revealed a clear hierarchy of affinities: BAG3 > BAG1 > Hsp105 >> BAG2. PMID: 24318877
11. HSPH1 and HSPH2 are bona fide chaperones on their own that collaborate with DNAJA1 and DNAJB1 to hydrolyze ATP and unfold polypeptides and HSPA1A and HSPH1 formed a powerful molecular machinery. PMID: 23737532
12. High HSP105 expression is associated with Barrett's esophagus. PMID: 22901192
13. It restricts aggregation of denaturated proteins,plays a role in protein folding in cytoplasms,and enhance expression of hsp70 in cell nucleus.(review) PMID: 22712230
14. The Hsp105-mediated multilevel regulation of DeltaF508 CFTR folding and quality control provides new opportunities to understand how chaperone machinery regulates the homeostasis and functional expression of misfolded proteins in the cell. PMID: 22505710
15. A direct correlation between HSP105 expression and lymphoma aggressiveness was also apparent. PMID: 21860023
16. Hsp105alpha and Hsp105beta suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of Hsp70. PMID: 20542028
17. Heat shock protein 105 is overexpressed in a variety of human tumors PMID: 14534695
18. HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process. PMID: 18083346
19. HSP105 analysis may be a helpful tool as a poor prognostic indicator and as a diagnostic aid in problematic lesions. PMID: 18477890
20. HSP 105 is thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSP 70. PMID: 19476517

Show More

Hide All

HGNC: 16969

OMIM: 610703

KEGG: hsa:10808

STRING: 9606.ENSP00000318687

UniGene: Hs.743267