HTRA2 Antibody

Datasheet
Code CSB-PA010902GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. O43464
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human HTRA2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias HtrA serine peptidase 2;HTRA2;OMI;PARK13;PRSS25 ;
Immunogen Species Homo sapiens (Human)
Target Names HTRA2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
HGNC 14348
RGD 1308906
MGI 1928676
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Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Involvement in disease 3-methylglutaconic aciduria 8 (MGCA8); Parkinson disease 13 (PARK13)
Subcellular Location Mitochondrion intermembrane space, Mitochondrion membrane, Single-pass membrane protein
Protein Families Peptidase S1C family
Tissue Specificity Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Database Links

HGNC: 14348

OMIM: 168600

KEGG: hsa:27429

STRING: 9606.ENSP00000258080

UniGene: Hs.469045

Pathway Apoptosis

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