IBSP Antibody

1. These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (BSP) and dentin sialoprotein (DSP)-in normal salivary gland cells. PMID: 27881474
2. In conclusion, serum levels of BSP, ALP, ICTP, and PSA increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value. PMID: 27323113
3. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2-Osterix-BSP Signaling. PMID: 26413977
4. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels. PMID: 26568273
5. Our results suggest that SSEA-4 is a specific cell surface antigen that can be used to identify dental pulp stem cells. PMID: 22266579
6. the strong correlation between bone sialoprotein and OPN and papillary thyroid carcinoma suggests a role for BSP and OPN in calcification and tumor progression of papillary thyroid carcinoma PMID: 25973097
7. oxidized low-density lipoprotein-induced expression dependent on Runx2 expression PMID: 25504218
8. Bone sialoprotein could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis. PMID: 24530278
9. Current evidence demonstrates that BSP and OPN, play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review] PMID: 24071501
10. High expression of bone sialoprotein in breast neoplasms was associated with cytokeratin-positive cells in bone marrow, but not with lymph node metastasis. PMID: 23726130
11. results indicate that FGF2 increases BSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human BSP gene. PMID: 23485603
12. BSP silencing decreased the integrin alphavbeta3 and beta3 levels, in turn inhibiting cell migration and invasion and decreasing the ability of the cells to metastasize to bone. PMID: 23667544
13. IBSP mRNA is over expressed in carotid atheroma plaque (3.74 fold, p = 1.41E-09) in an intraindividual comparison. PMID: 23314561
14. High BSP expression occurs in a significant subset of high-grade glioma patients and predicts a poorer outcome PMID: 23119009
15. HTRA1 has a central role in osteogenesis through modification of proteins within the extracellular matrix, in particular, ibsp. PMID: 22865667
16. human primary cementoblasts subjected to compression and IL-1beta stimulation impeded BSP and CEMP-1 expression, proteins that are associated with cementogenesis. PMID: 22349547
17. OPN plasma levels are associated with the genetic polymorphisms in integrin-binding sialoprotein gene locus (IBSP) PMID: 20967421
18. BSP protein expression in the primary resected non-small-cell lung cancer is strongly associated with bone metastasis and could be used to identify high-risk patients. PMID: 19376608
19. RT-PCR analysis of human bone marrow stromal cells during osteogenesis in vitro: the mRNA levels of bone morphogenetic protein-2 (BMP-2), bone sialoprotein-II (BSP), osteopontin (OP) and cbfa-1 increased with culture time in osteogenic medium. PMID: 11968014
20. has RGD sequence, affinity to collagen, and induces mineral crystal formation PMID: 11979972
21. Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. PMID: 12750290
22. BSP is expressed in breast and prostate cancer and has a role as a stimulator of bone mineralisation PMID: 14524533
23. The time course of the expression of BSP wss visualized after dental implnt implatation in mandibular bone fibroblasts. PMID: 15795688
24. Data show that RUNX2 is a direct regulator of bone sialoprotein in osteoblasts and that it functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. PMID: 16000302
25. Bone sialoprotein is involved in migration of bone marrow stromal cells through Matrigel and collagen barriers. PMID: 16995818
26. bone sialoprotein expression in the primary resected NSCLC is strongly associated with BM progression and could be useful in identifying high-risk patients who could benefit from novel modalities of surveillance and preventive treatment PMID: 17050866
27. May be a prognostic marker for bone metastasis in breast cancer. PMID: 17213971
28. Runx2 and HDAC3 repress BSP gene expression and that this repression is suspended upon osteoblastic cell differentiation. PMID: 17956871
29. has an angiogenic capacity; important in the differentiation of osteoblasts, bone matrix mineralization and tumor metastasis [review] PMID: 18302613
30. PTH stimulates human BSP gene transcription by targeting the two cAMP response elements in the promoter of the human BSP gene. PMID: 19127545
31. Studies do not support a role for BSP in promoting metastasis through interactions with pro-MMP-2. PMID: 19386107
32. cooperative mechanisms by which BSP can enhance specific factors associated with a metastatic phenotype in tumor cell lines, an effect that is increased by circulating TGF-beta1 and EGF. PMID: 19492334
33. Eight threonines modified by O-glycans were identified, leaving the C terminus of the protein free of glycans. The recombinant protein showed similar secondary structures as bone-derived BSP PMID: 11459848

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HGNC: 5341

OMIM: 147563

KEGG: hsa:3381

STRING: 9606.ENSP00000226284

UniGene: Hs.518726