IL12B Antibody

^{Rare Species}

Datasheet

Code	CSB-PA011587LA01SH
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Ovis aries (Sheep) IL12B Polyclonal antibody

Uniprot No.

P68220

Target Names

IL12B

Alternative Names

IL12B antibody; Interleukin-12 subunit beta antibody; IL-12B antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; CLMF p40 antibody; IL-12 subunit p40 antibody

Raised in

Rabbit

Species Reactivity

Sheep

Immunogen

Recombinant Sheep Interleukin-12 subunit beta protein (23-327AA)

Immunogen Species

Ovis aries (Sheep)

Conjugate

Non-conjugated

The IL12B Antibody (Product code: CSB-PA011587LA01SH) is Non-conjugated. For IL12B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA011587LB01SH	IL12B Antibody, HRP conjugated	ELISA
FITC	CSB-PA011587LC01SH	IL12B Antibody, FITC conjugated
Biotin	CSB-PA011587LD01SH	IL12B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.; Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene References into Functions

The aim of the study was to assess the prognostic significance of Tumor Necrosis Factor-alpha, Interleukin-12(p40), Interleukin-6 and Interleukin 10 levels in cerebrospinal fluid (CSF) in sheep with encephalitic listeriosis. PMID: 25817420
Local intraocular production of IL-12 p40 (but not IL-4) prolongs corneal graft survival significantly PMID: 16081789

Subcellular Location

Secreted.

Protein Families

Type I cytokine receptor family, Type 3 subfamily

Database Links

KEGG: oas:443472

UniGene: Oar.721

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Related pathways

Jak-STAT signaling pathway Th1 and Th2 cell differentiation Toll-like receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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