IL12RB1 Antibody

Datasheet
Code CSB-PA006274
Size US$167
Uniprot No. P42701
Image
  • Western Blot analysis of Hela cells using IL-12Rβ1 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of Human IL-12Rβ1.
Raised in Rabbit
Species Reactivity Human
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias IL12RB1; IL12R; IL12RB; Interleukin-12 receptor subunit beta-1; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL-12 receptor beta component; CD212
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Target Names IL12RB1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Involvement in disease Immunodeficiency 30 (IMD30)
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 2 subfamily
Database Links

HGNC: 5971

OMIM: 601604

KEGG: hsa:3594

STRING: 9606.ENSP00000403103

UniGene: Hs.567294

Pathway Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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