IL1RAPL1 Antibody

Code CSB-PA011624LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, SH-SY5Y whole cell lysate, U87 whole cell lysate
    All lanes: IL1RAPL1 antibody at 5.4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 80 kDa
    Observed band size: 80 kDa

  • IHC image of CSB-PA011624LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA011624LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IL1RAPL1 Polyclonal antibody
Uniprot No.
Target Names
IL1RAPL1
Alternative Names
IL 1 RAPL 1 antibody; IL 1RAPL 1 antibody; IL-1-RAPL-1 antibody; IL-1RAPL-1 antibody; IL1R8 antibody; IL1RAPL 1 antibody; IL1RAPL antibody; IL1RAPL-1 antibody; IL1RAPL1 antibody; Interleukin 1 receptor 8 antibody; Interleukin 1 receptor accessory protein like 1 antibody; Interleukin-1 receptor accessory protein-like 1 antibody; IRPL1_HUMAN antibody; Mental retardation X linked 10 antibody; Mental retardation X linked 21 antibody; Mental retardation X linked 34 antibody; MRX 21 antibody; MRX 34 antibody; MRX10 antibody; MRX21 antibody; MRX34 antibody; Oligophrenin 4 antibody; Oligophrenin-4 antibody; Oligophrenin4 antibody; OPHN 4 antibody; OPHN4 antibody; Three immunoglobulin domain containing IL 1 receptor related 2 antibody; Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody; TIGIRR 2 antibody; TIGIRR-2 antibody; TIGIRR2 antibody; X linked interleukin 1 receptor accessory protein like 1 antibody; X-linked interleukin-1 receptor accessory protein-like 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Interleukin-1 receptor accessory protein-like 1 protein (564-679AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The IL1RAPL1 Antibody (Product code: CSB-PA011624LA01HU) is Non-conjugated. For IL1RAPL1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011624LB01HU IL1RAPL1 Antibody, HRP conjugated ELISA
FITC CSB-PA011624LC01HU IL1RAPL1 Antibody, FITC conjugated
Biotin CSB-PA011624LD01HU IL1RAPL1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
Gene References into Functions
  1. Our study revealed that the expression of IL-1R8 significantly increased on in vitro-activated CD4+ T cells and was markedly higher on CD4+ T cells from allergic rhinitis patients than on cells from healthy controls. PMID: 29730558
  2. IL-1R8 serves as a checkpoint for NK cell maturation and effector function; its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection in mice PMID: 29072292
  3. Altered DNA methylation in IL1RAPL1 involves in the etiology of Bipolar disorder and Major Depressive disorder . PMID: 27440233
  4. rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in Latin American children. PMID: 28120837
  5. Our study expands the molecular repertoire of IL1RAPL1 mutations in intellectual disability and points out the need of more accurate clinical descriptions to better define the related phenotype PMID: 27470653
  6. It was indicated that a defect in IL1RAPL1 that controls excitatory synapsis formation results in the excitation-inhibition balance affecting various cerebral functions. PMID: 25864829
  7. Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis. PMID: 25305082
  8. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
  9. The IL1RAPL1 gene is of interest as a candidate gene for autism spectrum disorder as mutations or deletions in the gene have previously been reported in individuals from families with ASD. PMID: 21491612
  10. Intragenic deletions in IL1RAPL1are relevant to the pathogenesis of X-linked mental retardation. PMID: 21271657
  11. crystal structure at 2.3-A resolution of the TIR domain of IL-1RAPL PMID: 15123616
  12. Nearly all patients with deletions involving DAX1, but not DMD, had mental retardation if IL1RAPL1 was deleted. If ILIRAPLI & DMD were intact, the patients with DAX1 deletions only rarely had normal development. PMID: 15300857
  13. Report confirms the role of the IL1RAPL1 gene in causing nonspecific mental retardation in males. PMID: 16470793
  14. DMD gene and its immediately distal neighbor, the 1.8 Mb IL1RAPL1 gene are abundantly expressed in normal brain but were dramatically underexpressed in every brain tumor cell line and xenograft. PMID: 18253029
  15. Combined data suggested that IL1RAPL1 affected human cognitive ability to some extent, especially the memory and concentration capability. PMID: 18467032
  16. The function of truncated IL1RAPL1 protein in an autistic female with Asperger syndrome is severely altered in hippocampal neurons, demonstrated by its effect on neurite outgrowth activity. PMID: 18801879
  17. IL1RAPL1 plays an important role in the etiology of X-linked mental retardation. PMID: 19012350

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Involvement in disease
Mental retardation, X-linked 21 (MRX21)
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon. Cell projection, dendrite.
Protein Families
Interleukin-1 receptor family
Tissue Specificity
Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal live
Database Links

HGNC: 5996

OMIM: 300143

KEGG: hsa:11141

STRING: 9606.ENSP00000305200

UniGene: Hs.658912

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