IL5RA Antibody

Code CSB-PA009557
Size US$100
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Product Details

Uniprot No.
Target Names
Alternative Names
CD125 antibody; CD125 antigen antibody; CDw125 antibody; HSIL5R3 antibody; IL-5 receptor subunit alpha antibody; IL-5R subunit alpha antibody; IL-5R-alpha antibody; IL-5RA antibody; IL5R antibody; IL5RA antibody; IL5RA_HUMAN antibody; Interleukin 5 Receptor alpha antibody; Interleukin 5 Receptor alpha chain antibody; Interleukin 5 receptor alpha subunit antibody; Interleukin 5 receptor subunit alpha antibody; Interleukin 5 receptor type 3 antibody; Interleukin-5 receptor subunit alpha antibody; MGC26560 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the N-terminal region of Human IL-5Rα.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:5000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

This is the receptor for interleukin-5. The alpha chain binds to IL5.
Gene References into Functions
  1. Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response. PMID: 27682872
  2. Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review PMID: 26859368
  3. This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. PMID: 25523412
  4. This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. PMID: 24332579
  5. The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy. PMID: 23190752
  6. These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients. PMID: 23470716
  7. we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. PMID: 22153509
  8. IL-5Ralpha expression on eosinophils inversely correlated with eosinophilia and was significantly elevated in patients with systemic mastocytosis without eosinophilia PMID: 21762978
  9. Study of engineered deglycosylated IL-5 receptor alpha variant proves that unique carbohydrate groups in multiglycosylated receptors can be utilized asymmetrically for function. PMID: 21770429
  10. Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population. PMID: 21193198
  11. Increased serum level precedes the development of eczema in children PMID: 20735756
  12. findings indicate that retinoids can differentially regulate expression of IL-5Ralpha and that these effects have functional consequences in vitro on eosinophil and basophil differentiation PMID: 11842302
  13. findings are consistent with an airway tissue-selective expression of the IL-5 receptor that mediates IL-5-induced airway hyperresponsiveness independent of eosinophils PMID: 11897983
  14. expression of membrane IL-5Ralpha on bronchoalveolar lavage eosinophils following airway Ag challenge PMID: 12444154
  15. expression of membrane IL-5 receptor alpha on human eosinophils PMID: 12444155
  16. IL-5 receptor expression in cultured human eosinophils is downregulated by its ligand PMID: 12943658
  17. Our findings suggest that polymorphisms in IL5RA might be among the genetic risk factors for asthma development, especially in atopic populations. PMID: 16217591
  18. These data argue that the charged residues of AF17121 are utilized asymmetrically in the pathway of inhibitor-receptor complex formation to deactivate the receptor function PMID: 16430207
  19. These data establish a critical role for JAK kinases and the Ub/proteasome degradation pathway in IL-5R down-regulation. PMID: 17227823
  20. In chronic eosinophilic leukemia, there was a non-significant association between a SNP at rs4054760 and eosinophil count & IL5RA expression. There was no association with FIP1L1-PDGFRA positivity. PMID: 17914408
  21. The genetic association between CCR3 polymorphisms and the number of circulating eosinophils was revealed;it was more pronounced when the CCR3 polymorphisms were paired with polymorphisms in IL5RA. PMID: 17983872
  22. variants of IL5RA and TNFRSF6B may predispose to sporadic IgA nephropathy PMID: 18256354
  23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
  24. IL-5Rs segregate and traffic into two distinct plasma membrane compartments, and establish that IL-5R endocytosis regulates signaling both positively and negatively. PMID: 18511572
  25. The expression of SOL-IL-5Ralpha and TM-IL-5Ralpha differs according to the eosinophil activation state and localization in the body (blood vs tissue) and may therefore be involved in the fine-tuning of the eosinophil homeostasis. PMID: 19170670
  26. Syntenin forms complexes with multiple IL-5Ralpha chains PMID: 19654410

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Type I cytokine receptor family, Type 5 subfamily
Tissue Specificity
Expressed on eosinophils and basophils.
Database Links

HGNC: 6017

OMIM: 147851

KEGG: hsa:3568

STRING: 9606.ENSP00000256452

UniGene: Hs.68876

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