IL5RA Antibody

Code CSB-PA935849
Size US$166
Order now
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA935849(IL5RA Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA935849(IL5RA Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA935849(IL5RA Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
IL5RA
Alternative Names
CD125 antibody; CD125 antigen antibody; CDw125 antibody; HSIL5R3 antibody; IL-5 receptor subunit alpha antibody; IL-5R subunit alpha antibody; IL-5R-alpha antibody; IL-5RA antibody; IL5R antibody; IL5RA antibody; IL5RA_HUMAN antibody; Interleukin 5 Receptor alpha antibody; Interleukin 5 Receptor alpha chain antibody; Interleukin 5 receptor alpha subunit antibody; Interleukin 5 receptor subunit alpha antibody; Interleukin 5 receptor type 3 antibody; Interleukin-5 receptor subunit alpha antibody; MGC26560 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human IL5RA
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
This is the receptor for interleukin-5. The alpha chain binds to IL5.
Gene References into Functions
  1. Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response. PMID: 27682872
  2. Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review PMID: 26859368
  3. This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. PMID: 25523412
  4. This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. PMID: 24332579
  5. The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy. PMID: 23190752
  6. These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients. PMID: 23470716
  7. we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. PMID: 22153509
  8. IL-5Ralpha expression on eosinophils inversely correlated with eosinophilia and was significantly elevated in patients with systemic mastocytosis without eosinophilia PMID: 21762978
  9. Study of engineered deglycosylated IL-5 receptor alpha variant proves that unique carbohydrate groups in multiglycosylated receptors can be utilized asymmetrically for function. PMID: 21770429
  10. Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population. PMID: 21193198
  11. Increased serum level precedes the development of eczema in children PMID: 20735756
  12. findings indicate that retinoids can differentially regulate expression of IL-5Ralpha and that these effects have functional consequences in vitro on eosinophil and basophil differentiation PMID: 11842302
  13. findings are consistent with an airway tissue-selective expression of the IL-5 receptor that mediates IL-5-induced airway hyperresponsiveness independent of eosinophils PMID: 11897983
  14. expression of membrane IL-5Ralpha on bronchoalveolar lavage eosinophils following airway Ag challenge PMID: 12444154
  15. expression of membrane IL-5 receptor alpha on human eosinophils PMID: 12444155
  16. IL-5 receptor expression in cultured human eosinophils is downregulated by its ligand PMID: 12943658
  17. Our findings suggest that polymorphisms in IL5RA might be among the genetic risk factors for asthma development, especially in atopic populations. PMID: 16217591
  18. These data argue that the charged residues of AF17121 are utilized asymmetrically in the pathway of inhibitor-receptor complex formation to deactivate the receptor function PMID: 16430207
  19. These data establish a critical role for JAK kinases and the Ub/proteasome degradation pathway in IL-5R down-regulation. PMID: 17227823
  20. In chronic eosinophilic leukemia, there was a non-significant association between a SNP at rs4054760 and eosinophil count & IL5RA expression. There was no association with FIP1L1-PDGFRA positivity. PMID: 17914408
  21. The genetic association between CCR3 polymorphisms and the number of circulating eosinophils was revealed;it was more pronounced when the CCR3 polymorphisms were paired with polymorphisms in IL5RA. PMID: 17983872
  22. variants of IL5RA and TNFRSF6B may predispose to sporadic IgA nephropathy PMID: 18256354
  23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
  24. IL-5Rs segregate and traffic into two distinct plasma membrane compartments, and establish that IL-5R endocytosis regulates signaling both positively and negatively. PMID: 18511572
  25. The expression of SOL-IL-5Ralpha and TM-IL-5Ralpha differs according to the eosinophil activation state and localization in the body (blood vs tissue) and may therefore be involved in the fine-tuning of the eosinophil homeostasis. PMID: 19170670
  26. Syntenin forms complexes with multiple IL-5Ralpha chains PMID: 19654410

Show More

Hide All

Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Type I cytokine receptor family, Type 5 subfamily
Tissue Specificity
Expressed on eosinophils and basophils.
Database Links

HGNC: 6017

OMIM: 147851

KEGG: hsa:3568

STRING: 9606.ENSP00000256452

UniGene: Hs.68876

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*