ITGAD Antibody

Datasheet

Code	CSB-PA005837
Size	US$100
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Image	Western Blot analysis of 4T1, 293 cells using Integrin αD Polyclonal Antibody.
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Product Details
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Target Background

Product Details

Uniprot No.

Q13349

Target Names

ITGAD

Alternative Names

ITGAD antibody; Integrin alpha-D antibody; ADB2 antibody; CD11 antigen-like family member D antibody; Leukointegrin alpha D antibody; CD antigen CD11d antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human Integrin αD.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Gene References into Functions

findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development. PMID: 28500072
These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease. PMID: 27881604
alpha(D)beta(2) is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans PMID: 25415295
The effects of anti-CD11d treatment improves functional recovery in a rat model of repeated concussion. PMID: 23414334
the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively. PMID: 21712539
CD11d expression increased in the subcutaneous white adipose tissue of obese adult women; this appears to be a common feature of obesity. PMID: 21508205
a longer isoform of gut-enriched Kruppel-like factor 4 (GKLF) we term GKLFa interacts with the CD11d promoter PMID: 15561714
multiple CD11d domains play a role in controlling intracellular location and association with CD18. PMID: 19571252

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Integrin alpha chain family

Tissue Specificity

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Database Links

HGNC: 6146

OMIM: 602453

KEGG: hsa:3681

STRING: 9606.ENSP00000373854

UniGene: Hs.679163

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Regulation of actin cytoskeleton

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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